MLB Home Run Predictions Today: Best HR Prop Bets, Picks, Parlay & Odds for Saturday, April 25

Quinn Allen - Betting Analyst at Covers.com
Quinn Allen • Betting Analyst 7+ years betting experience
Updated: Apr 25, 2026 , 09:57 AM ET • 4 min read

Allen's prediction: Alvarez goes deep again.

Yordan Alvarez Houston Astros MLB
Photo By - Reuters Connect. Houston Astros designated hitter Yordan Alvarez reacts after hitting a home run.

It’s another busy slate across the Major Leagues for Saturday, April 25.

My MLB player props home run analysis will include Tyler O’Neill, Randy Arozarena, and Yordan Alvarez.

Read more for my MLB picks for Saturday, April 25. 

  • UPDATE: Added another HR pick + parlay.

Best MLB home run props today

Player to hit a HR Odds
Orioles Tyler O'Neill +490
Mariners Randy Arozarena +440
Astros Yordan Alvarez +290
💲Today's HR parlay +11272
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Tyler O'Neill (+440)

Tyler O’Neill isn’t having the best campaign so far, hitting just .241 with one home run. However, it’s well known that the slugger has big-time power, and he can go deep at any given moment. He’ll face his former team today in the Boston Red Sox, with Garret Crochet on the mound.

Crochet has struggled. He owns a horrible 7.88 ERA through five starts, allowing five bombs in the process. Three of them have come on the road, and the Red Sox visit the Baltimore Orioles. O’Neill is 1-for-5 lifetime off the lefty with a homer. His only long ball this year was at Camden Yards as well.

  • Time: 12:05 p.m. ET
  • Where to watch: MASN

Randy Arozarena (+440)

Randy Arozarena is also getting to face his ex-team today, the St. Louis Cardinals. The Seattle Mariners star will see another struggling lefty on the hill in Matthew Liberatore. He’s already given up five home runs, and opponents are hitting .269.

Arozarena is 2-for-5 lifetime against him with a home run, and he’s 3-for-7 across his last two games with a pair of doubles. Arozarena is also batting .364 against left-handed pitchers, and .314 on the road. Liberatore has allowed three homers at Busch Stadium.

  • Time: 2:15 p.m. ET
  • Where to watch: Mariners.TV

Yordan Alvarez (+290)

Yordan Alvarez sits atop the big leagues in home runs with 11, and he’s also first in hits (35) and average (.357). The slugger is raking, going 7-for-12 across his last three contests. He’s left the yard four times across his previous seven appearances as well.

The Houston Astros star faces Ryan Weathers of the New York Yankees tonight. While he’s never faced him before, Weathers has surrendered four bombs in five outings. Alvarez also destroys lefties, hitting .424 with five home runs.

  • Time: 7:10 p.m. ET
  • Where to watch: YES Network
Quinn Allen's 2026 Transparency Record
  • HR picks: 5-24, +1.22 units

Today’s HR parlay

Orioles Tyler O'Neill Bet Now
+11272
Mariners Randy Arozarena
Astros Yordan Alvarez

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Quinn Allen - Covers
Betting Analyst

Quinn Allen is an experienced sports journalist from Vancouver, Canada who fell in love with sports by the time he could walk. He proceeded to play high-level baseball and soccer growing up and eventually played college baseball in the United States.

After his career ended, Quinn received his broadcast journalism degree from BCIT and has since written for many sports publications including ClutchPoints, Gino Hard, and RG, where he plies his trade as a writer and editor.

Quinn's favorite team is Chelsea FC and he'd like to watch a match at Stamford Bridge one day. He loves to bet on NBA player props and encourages others to bet responsibly and not chase losses.

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