The Cleveland Guardians begin this divisional series as small -115 favorites against the Chicago White Sox.
Their bats have a good matchup against Anthony Kay, which is why my Guardians vs. White Sox predictions and MLB picks see value in backing the road team to take care of business on June 22.
Who will win Guardians vs White Sox today: Guardians (-115)
The Cleveland Guardians have an immense pitching advantage over the Chicago White Sox, with Gavin Williams set to take the bump opposite Anthony Kay.
Williams has held batters to a .220 average while striking them out at a very healthy 27.9% clip. His 3.29 xFIP is lower than his 3.89 ERA, indicating his strong first half is more than sustainable.
Kay ranks in the 10th percentile in Pitcher Run Value and xBA. His struggles are starting to catch up to him, allowing 12 runs over 13 innings in the past three starts.
Back the Guardians to -130.
COVERS INTEL: Anthony Kay owns a 3.08 ERA at home despite a 4.88 xFIP, a sign regression could bite him moving forward.
Guardians vs White Sox Over/Under pick: Over 8 (+100)
The Guardians are not a prolific offensive team against lefties, but they have fared better on the road, sitting 19th in OBP and third in hard-hit rate.
Kay has bled runs while allowing 1.86 homers per nine innings over the last month. Led by Kyle Manzardo, the Guardians have some bats who can take advantage of struggling lefties.
While Williams is an excellent pitcher, he owns a 4.94 ERA and 1.90 HR/9 on the road — much worse than his home outputs.
Chicago should chip in 3-4 runs, making the Over an appealing buy to -115.
- ML/RL bets: 38-28, +2.15 units
- Over/Under bets: 35-27-4, +4.69 units
Guardians vs White Sox weather
Temperatures in the low 60s are expected. However, there could be winds of close to 15 mph blowing from the northeast. That could help balls carry further and boost bats.
Guardians vs White Sox odds
- Moneyline: Guardians -115 | White Sox -105
- Run line: Guardians -1.5 (+155) | White Sox +1.5 (-180)
- Over/Under: Over 8.0 (+100) | Under 8.0 (-120)
Guardians vs White Sox trend
Cleveland has hit the moneyline in 29 of its last 50 away games (+14.15 units, 27% ROI). Find more MLB betting trends for Guardians vs. White Sox.
How to watch Guardians vs White Sox and game info
| Location | Rate Field, Chicago, IL |
| Date | Monday, June 22, 2026 |
| First pitch | 7:40 p.m. ET |
| TV | CleGuardians.TV, CHSN |
| Guardians starting pitcher | Gavin Williams (9-4, 3.83 ERA) |
| White Sox starting pitcher | Anthony Kay (6-2, 4.61 ERA) |
Guardians vs White Sox latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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