Guardians vs Tigers Prediction, Picks & Odds for Today's MLB Game

Jason Ence - Contributor at Covers.com
Jason Ence • Betting Analyst 13+ years betting experience
Updated: May 18, 2026 , 01:27 PM ET • 4 min read

The Tigers will take the series opener with the Guardians given the starting pitching mismatch, per our MLB expert.

MLB

Match starts: 4 hrs
CLE
48 %
DET
52 %
EXPERT PICK - MONEYLINE
Detroit -145 Detroit -145
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Detroit Tigers MLB Framber Valdez
Photo By - Reuters Connect. Detroit Tigers starting pitcher Framber Valdez.

The Detroit Tigers look for just their third win in 13 games when they host the Cleveland Guardians on Monday night.

Cleveland leads the AL Central thanks to picking up five wins in a six-game span. However, my Guardians vs. Tigers predictions are fading the visitors with Slade Cecconi taking the bump.

Here are my MLB picks for May 18.

Who will win Guardians vs Tigers today: Tigers moneyline (-145)

Slade Cecconi is getting pummeled by opposing hitters. His 5.60 ERA and 5.05 FIP rank among the worst in the majors for pitchers with at least 40 innings pitched.

Opponents have posted a .595 xSLG vs. Cecconi's fastball this year. He’s also performed far worse on the road, with a 6.60 ERA vs. a 3.60 home ERA. 

Framber Valdez has put up quality numbers in seven of nine starts. He’s facing a Cleveland Guardians lineup ranked 21st in hard-hit rate and eighth in ground-ball rate vs. RHP over the past two weeks.   

Covers COVERS INTEL: Ceconi has posted an astronomical 19.96 ERA against hitters facing him a third time this season.

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Guardians vs Tigers Over/Under pick: Under 8.5 (-128)

Once the starters give way to the bullpens, scoring will get much more difficult. 

Over the past two weeks, the Detroit Tigers rank 29th in hard-hit rate, and dead last in HR/FB rate and wRC+. Cleveland’s pen ranks second in K-rate in that span.

Detroit’s pen has forced a league-high 55.2% GB rate during that timeframe. That’ll come in handy, seeing as the Guardians have posted the fourth-highest GB/FB rate while ranking 25th in BABIP. 

Cleveland punished the poor-pitching Reds this weekend, but will regress to the mean today for another Under. 

Jason Ence's 2026 Transparency Record
  • ML/RL bets: 6-10, -4.67 units
  • Over/Under bets: 11-5, +5.74 units

Guardians vs Tigers odds

  • Moneyline: Guardians +138 | Tigers -144
  • Run line: Guardians +1.5 (-156) | Tigers -1.5 (+150)
  • Over/Under: Over 8.5 (+117) | Under 8.5 (-122)

Guardians vs Tigers trend

The Tigers have hit the Under in 7 of their last 10 games (+3.70 Units / 34% ROI). Find more MLB betting trends for Guardians vs. Tigers.

How to watch Guardians vs Tigers and game info

Location Comerica Park, Detroit, MI
Date Monday, May 18, 2026
First pitch 6:40 p.m. ET
TV FS1
Guardians starting pitcher Slade Cecconi
(2-4, 5.60 ERA)
Tigers starting pitcher Framber Valdez
(2-2, 4.32 ERA)

Guardians vs Tigers latest injuries

Guardians vs Tigers weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Jason Ence - Covers
Betting Analyst

Jason has been hooked on football since watching Real Madrid and Manchester United in the 2003 Champions League, and has been betting on the sport for nearly 15 years. He has given soccer gambling and fantasy advice for nearly a decade, writing for sites including Rotowire, SB Nation, and The TwinSpires Edge.

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