The Baltimore Orioles are 55% favorites to put an end to their six-game losing streak this afternoon at Camden Yards, with first pitch coming at 1:35 p.m. ET.
Given the strong signs they've shown at the plate against left-handed pitchers, I'm buying the dip and backing Baltimore with my Guardians vs. Orioles predictions and MLB picks.
Who will win Guardians vs Orioles today: Orioles moneyline (55%)
For help understanding probabilities, see our odds calculator.
The Baltimore Orioles’ hitting profile against lefties is littered with green flags.
They rank second in barrel rate, second in hard-hit rate, and fifth in xwOBA vs. southpaws over the past month. Joey Cantillo has posted a 1.52 WHIP and 5.09 SIERA during that span, making him a vulnerable target the Orioles should get to.
Trevor Rogers managed a 1.22 WHIP and 3.04 SIERA over the same period. He looks more likely to give his team a quality start, and the Orioles have the better offense to boot.
Back Baltimore to 57%.
COVERS INTEL: Joey Cantillo's 1.52 WHIP over the past 30 days is the fourth-highest mark among today's projected starters.
Guardians vs Orioles Over/Under pick: Over 7.5 (55%)
Cantillo has not fared well against teams that hit lefties for power. He's sporting a 6.75 ERA through 10 starts vs. opponents who rank inside the Top 10 in ISO against southpaws, and the Orioles come in at No. 9.
All of Baltimore’s underlying numbers are pointing upwards against lefties, so this is a spot I want to back them to score.
The Cleveland Guardians are not the most powerful offense around, but they quietly sit 11th in xwOBA against lefties the past month.
I’d play the Over to 57%.
Guardians vs Orioles home run prediction: Coby Mayo (16%)
Coby Mayo destroys left-handed pitching. He's sporting a .412 ISO and 22.6% barrel rate on the season, which is almost unfathomable.
He isn’t a one-trick pony, either. He hits almost everything well from lefties, and there’s nothing Cantillo has in his bag that should cause Mayo problems.
Fastballs, curveballs, and changeups account for well over 90% of Cantillo’s pitches against righties. Mayo hits them all for power, posting ISOs of .429, .727, and .367, respectively.
- ML/RL bets: 103-91, -9.0 units
- Over/Under bets: 99-89-6, -2.32 units
Guardians vs Orioles weather
The forecast calls for temperatures hovering around 80, although winds are blowing in. That'll zap some of the power.
Guardians vs Orioles odds
- Moneyline: Guardians 46% | Orioles 55%
- Run line: Guardians +1.5 (65%) | Orioles -1.5 (36%)
- Over/Under: Over 7.5 (55%) | Under 7.5 (46%)
Guardians vs Orioles trend
The Orioles own a 71-69 O/U record this season. Find more MLB betting trends for Guardians vs. Orioles.
How to watch Guardians vs Orioles and game info
| Location | Oriole Park at Camden Yards, Baltimore, MD |
| Date | Monday, September 7, 2026 |
| First pitch | 1:35 p.m. ET |
| TV | CleGuardians.TV, MASN |
| Guardians starting pitcher | Joey Cantillo (9-8, 3.81 ERA) |
| Orioles starting pitcher | Trevor Rogers (9-9, 4.30 ERA) |
Guardians vs Orioles latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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