Rafael Devers is one of the most dangerous left-handed hitters in the majors.
A lot of his production comes against right-handed pitching, and my Giants vs. Padres predictions and MLB picks see him taking advantage of a gettable righty in German Marquez.
Giants vs Padres predictions
Giants vs Padres best bet: Rafael Devers Over 1.5 hits + runs + RBI (-135)
Rafael Devers has a mouthwatering matchup to jumpstart his campaign against German Marquez.
The veteran pitcher struggled mightily with lefties last season, allowing a .311 average, .396 wOBA, and 1.71 homers per nine innings.
Devers is a prime candidate to take advantage. Isolating Marquez’s three most-used pitchers against left-handed bats, Devers posted a .355 OBP and 59.9% hard hit rate against righties last season. Focus on Marquez’s two go-to pitches, and that hard hit rate spikes to 63.4%.
Devers should generate good contact in this matchup, and good things tend to happen when he does.
COVERS INTEL: Rafael Devers has posted an average exit velocity of 94.5 miles per hour over the last 10 balls put in play against Marquez’s pitch mix.
Giants vs Padres same-game parlay (SGP)
Jung Hoo Lee is another lefty poised to cause Marquez problems. He hit .286 against Marquez’s three most prominent pitches last season while striking out only 7% of the time. He’s great at getting the bat on the ball and generating contact, while Marquez struggles to miss bats.
Ace Logan Webb will take the bump for the Giants, and he is already ramped up from the WBC and starting the MLB’s season opener. He is a quality start machine, and the Giants are poised to provide him run support against Marquez.
Giants vs Padres SGP
- Rafael Devers Over 1.5 hits + runs + RBI
- Jung Hoo Lee Over 0.5 hits
- Giants moneyline
Giants vs Padres home run pick: Matt Chapman (+360)
Matt Chapman has made a lot of powerful contact out of the gate. He's responsible for the three hardest hit balls the Giants have this season, indicating the production is not far off.
Chapman has enjoyed a lot of success against Marquez in his career. He is 6-for-15 with four hits going for extra bases, three of which left the park.
Giants vs Padres odds
- Moneyline: San Francisco -135 | San Diego +115
- Run line: San Francisco -1.5 (+125) | San Diego +1.5 (-145)
- Over/Under: Over 7.5 | Under 7.5
Giants vs Padres trend
Rafael Devers has cleared 1.5 hits + runs + RBI in four consecutive games working on zero days of rest. Find more MLB betting trends for Giants vs. Padres.
How to watch Giants vs Padres and game info
| Location | Petco Park, San Diego, CA |
| Date | Tuesday, March 31, 2026 |
| First pitch | 9:40 p.m. ET |
| TV | NBCS-Bay Area, SDPA |
| Giants starting pitcher | Logan Webb (0-1, 10.80 ERA) |
| Padres starting pitcher | German Marquez (2025: 3-16, 6.70 ERA) |
Giants vs Padres latest injuries
Giants vs Padres weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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