The Milwaukee Brewers host the Chicago Cubs in this winner-take-all Game 5 of the NLDS tonight.
MLB odds list Milwaukee as a -130 favorite, while the total sits at 7.5.
My Cubs vs. Brewers predictions expect Milwaukee to survive a series collapse and prevail at home.
Read more in my MLB picks for Saturday, October 11.
First pitch is set for 8:08 p.m. ET from American Family Field, with the game airing on TBS.
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Cubs vs Brewers Game 5 predictions
Who will win Cubs vs Brewers Game 5
The Milwaukee Brewers are listed as a -130 favorite, and they should fulfill expectations of closing out this series.
Milwaukee went with a bullpen game en route to a 7-3 victory in Game 2, and a similar outcome is likely this evening.
Cubs vs Brewers best bet
Milwaukee Brewers moneyline (-130)
The home team has won each game in this series, a trend likely to continue in Game 5. Both teams are going with bullpen games, which gives the pitching advantage to the Milwaukee Brewers.
This season, the Brewers’ relief corps finished sixth in ERA, fourth in xERA, fifth in FIP, and fifth in WAR. Meanwhile, the Chicago Cubs' relief staff ranked 11th or lower in each of those four key categories.
Not only will Milwaukee own the pitching advantage on its home field, but it also possesses the hitting advantage. In 2025, the Brewers ranked in the top three in runs scored per game, hits per game, stolen bases, and on-base percentage.
Milwaukee has won five of the past six meetings between these two teams at American Family Field, with each of those five wins coming by at least a four-run margin.
Cubs vs Brewers Game 5 same-game parlay (SGP)
Milwaukee needs production at the plate to secure this victory, and there is no better candidate to deliver than Jackson Chourio.
A postseason star, Chourio boasts a .462 batting average, .885 slugging percentage, and 1.366 OPS through 26 playoff at-bats.
Meanwhile, William Contreras thrives at home, where he has recorded three or more total bases in each of the team’s two games this postseason.
Cubs vs Brewers SGP (+400)
- Milwaukee Brewers moneyline (-130)
- Jackson Chourio Over 1.5 total bases (-103)
- William Contreras Over 1.5 total bases (+125)
Cubs vs Brewers home run pick for Game 5
William Contreras (+500)
In the second of those two home games, Contreras homered. Although Drew Pomeranz is opening for Chicago tonight, one name almost guaranteed to appear is Colin Rea.
Through seven plate appearances against Rea, Contreras boasts a .571 slugging percentage and a .617 expected slugging percentage.
Cubs vs Brewers Game 5 odds
- Moneyline: Chicago +110 | Milwaukee -130
- Run line: Chicago +1.5 (-210) | Milwaukee -1.5 (+170)
- Over/Under: Over 7.5 (-110) | Under 7.5 (-110)
Cubs vs Brewers trend
Milwaukee has won five of its past six home games against Chicago. Find more MLB betting trends for Cubs vs. Brewers.
How to watch Cubs vs Brewers and Game 5 info
| Location | American Family Field, Milwaukee, WI |
| Date | Saturday, October 11, 2025 |
| First pitch | 8:08 p.m. ET |
| TV | TBS |
| Cubs starting pitcher | Drew Pomeranz (2-2, 2.17 ERA) |
| Brewers starting pitcher | Trevor Megill (5-3, 2.54 ERA) |
Cubs vs Brewers latest injuries
Cubs vs Brewers weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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