Blue Jays Picks, Predictions & Best Bets for ALCS Game 6 on October 19

The Blue Jays are leaning on Trey Yesavage in a win-or-go-home Game 6 against the Mariners, and our MLB picks expect him to bring his best stuff.

Mike DiStefano - Contributor at Covers.com
Mike DiStefano • Betting Analyst
Oct 19, 2025 • 13:12 ET • 4 min read
Trey Yesavage Toronto Blue Jays MLB
Photo By - Imagn Images. Trey Yesavage pitches in Game 2 against the Mariners.

It’s a do-or-die Game 6 for the Toronto Blue Jays tonight as the series shifts back to Rogers Centre.

The Jays are sending star rookie Trey Yesavage to the hill, and I expect him to rise to the occasion much like he has at every other level this season. 

Find out how I’m backing Yesavage with my free Blue Jays predictions and MLB picks for tonight's big game. 

Blue Jays predictions for ALCS Game 6

Pick Bet99
Trey Yesavage Over 4.5 strikeouts +105
• Trey Yesavage Over 4.5 strikeouts
• Vladimir Guerrero Jr. Over 1.5 total bases
• Nathan Lukes Over 1.5 total bases
+600

Get a first bet encore up to $800 — no BET99 promo code neededGet a first bet encore up to $800 with BET99 bonus code COVERSMLB.
(not available in Ontario)

Blue Jays ALCS Game 6 best bet: Young buck shines bright!

Trey Yesavage Over 4.5 strikeouts (+105 at BET99)

The Toronto Blue Jays are in a win-or-go-home situation, and they’re relying on rookie starter Trey Yesagave to keep their season alive. The kid has moxie and is full of confidence. 

After being named to the starting playoff rotation ahead of the ALDS, he said he was built for this. He went on to strike out 11 Yankee batters in five shutout innings.

He has electric stuff and is averaging 6.2 strikeouts per game over his brief five major league outings. The Seattle Mariners' strikeout numbers have been abysmal in this postseason, too, with a 27% strikeout rate. 

That number rises to 31% against the splitter, which is Yesavage’s put-away pitch that counts for 50% of his total strikeouts while garnering a 57.1% whiff rate on it.

Today’s Blue Jays Game 6 same-game parlay (SGP)

Trey Yesavage Over 4.5 strikeouts

Vladimir Guerrero Jr. Over 1.5 total bases

Nathan Lukes Over 1.5 total bases

I'll continue to bet on Vladimir Guerrero Jr. to go Over 1.5 total bases. He’s gone Over the number in three straight games and has a 1.245 career OPS with four extra-base hits against Seattle starter Logan Gilbert.

I’ll also take Nathan Lukes to go Over 1.5 bases as well; he’s got the hottest bat on the team with six hits in his last four games and was 2-for-2 against Logan Gilbert

Live Blue Jays odds for today

How to watch Blue Jays Game 6

Location Rogers Centre, Toronto, Ontario
Date Sunday, October 19, 2025
First pitch 8:03 p.m. ET
TV Rogers Sportsnet
Blue Jays starting pitcher Trey Yesavage
(1-1, 4.82 ERA)
Mariners starting pitcher Logan Gilbert
(1-0, 2.45 ERA)

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Mike DiStefano - Covers
Betting Analyst

Mike DiStefano joins Covers after a successful five-year stint with TSN. Distefano hosted Leafs Lunch, a Toronto Maple Leafs-centric radio show which featured a daily best bets segment where he found the biggest and best value plays of the night. He was also a weekly staple on TSN's flagship radio/tv show "OverDrive" as a betting analyst during their NFL picks segment #TeamAl-DogForever.

A graduate of Centennial College’s Sports Journalism program, Mike has also contributed to the Canadian Baseball Network, FanSided, and The Hockey News.

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