The Milwaukee Brewers host the Houston Astros in the second matchup of this three-game series at American Family Field. MLB odds list this game as a pick ‘em, while the total sits at 8.
My Astros vs. Brewers prediction targets the total in this interleague matchup.
Astros vs Brewers prediction
My Astros vs Brewers best bet: Over 8 (-110 at FanDuel)
Right-hander Hayden Wesneski takes the mound for the Houston Astros, and he is a good sell-high candidate. Through five starts this season, Wesneski owns a 3.86 ERA and 1.00 WHIP.
Meanwhile, the Milwaukee Brewers hand the ball to right-handed rookie Chad Patrick. Through seven appearances, Patrick boasts a 2.87 ERA and 1.28 WHIP.
However, like Wesneski, Patrick’s analytics indicate regression may be coming. The rookie ranks in the bottom half of the league in xBA, average exit velocity, strikeout rate, and hard-hit rate.
The good news for Patrick is that Milwaukee does a tremendous job manufacturing runs. Entering this matchup, the Brewers rank 10th in runs scored per game, mainly due to their strong ability to get on base and steal bases.
Furthermore, this current Milwaukee roster boasts a .401 expected slugging percentage (xSLG) and .339 expected weighted on-base average (xwOBA) through 24 combined plate appearances against Wesneski.
Astros vs Brewers same-game parlay (SGP)
Over 8
Jeremy Pena 1+ hits
Jose Altuve 1+ hits
If we’re backing the Over, then there need to be some hits. There may not be two better candidates to deliver than Jeremy Pena and Jose Altuve.
Altuve doubled in last night’s outing, marking his sixth hit over the past seven games. Meanwhile, Peña has recorded at least one hit in 23 of his past 24 games.
Learn how to bet a same-game parlay with these helpful tips and strategies.
Astros vs Brewers odds
Astros vs Brewers live odds
Astros vs Brewers opening odds
- Moneyline: Houston -108 | Milwaukee -108
- Run line: Houston -1.5 (+162) | Milwaukee +1.5 (-196)
- Over/Under: Over 8 (-110) | Under 8 (-110)
Astros vs Brewers trend
There have been nine or more total runs scored in seven of Houston’s past eight games. Find more MLB betting trends for Astros vs. Brewers.
How to watch Astros vs Brewers and game info
| Location | American Family Field, Milwaukee, WI |
| Date | Tuesday, 5-6-2025 |
| First pitch | 7:40 p.m. ET |
| TV | Space City Home Network, FanDuel Sports Network Wisconsin |
| Astros starting pitcher | Hayden Wesneski (1-2, 3.86 ERA) |
| Brewers starting pitcher | Chad Patrick (1-3, 2.87 ERA) |
Astros vs Brewers latest injuries
Astros vs Brewers weather
Not intended for use in MA.
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