Amanda & Rune to win a set - NO (2.10)
Taylor Tawson is now ranked #1 in the world in double, and I can't see them lose a set against the teens. Shelter is also in great form, the two played mixed double in US open back in 2023 and reached the semi-final against real double players, and only lost 1 set in 4 matches.
Amanda is 1-3 in Mixed and 0-5 on hard in doubles. Rune 1-4 mixed and haven't played much double lately, he last his last 3 hard court matches, all as favorite. He won some double matches with Tsitipas back in 2022.
Shelton has played over 100 double matches (53-54), played 2 matches last week in Toronto and won both with Fils before they withdraw.
Townsend who is 23-4 this year on hard (Won Washington, Dubai and AO) looking really good and have a good chance to win the US open this year (Final 2022, QF 2023, SF 2024) but I think she want to win this mixed, her first mixed title and this year is a bit extra with all the top single players.
I don't think Rune and Amanda or most of the single players cares about this at all, and I'm sure a US player will win. I think we will see Shelton / Townsend vs Draper/Pegula in the final.