There's still time to finalize your Panthers vs. 49ers predictions for Monday Night Football tonight, and our NFL experts are here to help!
Check out our Panthers vs. 49ers best bets and free NFL picks for November 24.
Panthers vs 49ers MNF predictions
- Panthers +7.5 (-115 at bet365)
- Under 49.5 (-110 at bet365)
- Dowdle anytime TD (-140 at bet365)
- Kittle o59.5 rec yds (-110 at bet365)
Panthers vs 49ers MNF best bets
Panthers +7.5
Josh Inglis likes the San Francisco 49ers on the moneyline, but believes the Carolina Panthers can keep things respectable.
"Carolina is 2-1 ATS as a TD-or-more dog, but one of those was +7.5 in Week 2 vs the Cardinals. The 49ers were just 3.5-point favorites vs. the Cardinals on the road, and I don't see too much difference in Arizona and Carolina, while including the venue swap, which is less than 3 points. I'd rather Carolina at +7.5."
Under 49.5
Inglis doesn't expect the Panthers to play their part in sending this game Over the total.
"This is the highest total the Panthers have seen all year, and don't forget the Falcons were coming back from Germany when they lost in OT last week to the Panthers. Before Week 11, this Carolina offense scored 13, nine, 16, and seven points."
Panthers vs 49ers MNF TD picks
Rico Dowdle anytime TD
Ryan Gilbert sees Rico Dowdle staying hot and hitting paydirt on MNF.
"Dowdle leads the Panthers with six TDs on the season after signing in Carolina in the offseason. There aren’t a ton of offensive weapons on the Panthers, so Dowdle has become their go-to back... The 49ers have allowed a touchdown to RBs in two straight games."
Panthers vs 49ers MNF props
George Kittle Over 59.5 receiving yards
Jason Logan is looking for George Kittle to put on a show in San Francisco tonight.
"George Kittle loves the bright lights of prime time and also loves picking apart zone coverage. The San Francisco 49ers’ tight end will see plenty of that against a Carolina Panthers secondary running the highest rate of zone schemes in the NFL. Kittle is great at find gaps and is Brock Purdy’s favorite option in those spots, rating as the top TE vs. zone at PFF."
Panthers vs 49ers odds
Panthers vs 49ers game info
| Location: | Levi's Stadium, San Francisco, CA |
| Date: | Monday, November 24, 2025 |
| Kickoff: | 8:15 p.m. ET |
| TV: | ESPN |
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