Monday Night Football matchups don't get much better than this.
A potential Super Bowl preview is in store at M&T Bank Stadium tonight as the Detroit Lions visit the Baltimore Ravens.
Our experts lay out their best Lions vs. Ravens predictions and NFL picks for Monday, September 22.
Lions vs Ravens MNF predictions
- Lions +4.5 (-110 at bet365)
- Over 53.5 (-110 at bet365)
- Flowers anytime TD (+110 at bet365)
- Gibbs o24.5 rec yds (-110 at bet365)
Lions vs Ravens MNF best bets
Lions +4.5
NFL expert Josh Inglis likes the points with the Detroit Lions over the Baltimore Ravens tonight.
"This opened Baltimore -5.5 and has moved to -4.5. Detroit rebounded nicely in Week 2 and gained some confidence in the market. THE BLITZ has this game at Baltimore -3.31. The backdoor is wide open for the Lions in this game."
Over 53.5
Inglis lays out the case for the Over despite a sky-high total.
"This total opened at 51 and has hit as high as 53. It's the highest total of the season. It's a giant total but the Ravens have scored 40+ in each game this year and the Lions bounced back in Week 1 vs the best defense in football to hang a 52-pack vs. the Bears. Neither defense has impressed either this season and both teams could score 25+ on Monday night."
Lions vs Ravens MNF TD picks
Zay Flowers
Ed Scimia is excited about the odds on Zay Flowers in this market, as he's been a favorite target of Lamar Jackson this year.
"Jackson has thrown 48 passes this year. Flowers has been the target for 20 of those, totaling 218 yards and a touchdown on 14 catches. He has more than half of the Ravens’ total receiving yards, and more than three times as many receptions as any other player in the offense. That level of usage will inevitably result in scores."
Lions vs Ravens MNF props
Jahmyr Gibbs Over 24.5 receiving yards
Ryan Gilbert is counting on Jahmyr Gibbs' abilities as a pass-catcher to be heavily utilized by the Lions on Monday night.
"Gibbs was used primarily in the passing game as the Lions played from behind in Week 1, hauling in all 10 targets for 31 yards in Green Bay. The third-year back had at least 25 receiving yards in 10 of 17 games last season, plus in his only postseason game."
Lions vs Ravens odds
Lions vs Ravens game info
| Location: | M&T Bank Stadium, Baltimore, MD |
| Date: | Monday, September 22, 2025 |
| Kickoff: | 8:15 p.m. ET |
| TV: | ESPN |
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