Eagles vs Packers Predictions - Early Picks & Odds for Monday Night Football Week 10

Ponnaiya's prediction: Hurts delivers at Lambeau.

Rohit Ponnaiya - Betting Analyst at Covers.com
Rohit Ponnaiya • Betting Analyst
Nov 4, 2025 • 15:08 ET • 4 min read
 Philadelphia Eagles quarterback Jalen Hurts (1) runs off the field.
Photo By - Imagn Images. Philadelphia Eagles quarterback Jalen Hurts (1) runs off the field.

The Philadelphia Eagles lock horns with the Green Bay Packers in Monday Night Football in Week 10. The Eagles are fresh off their bye after back-to-back wins, while the Pacers are coming off an upset loss on Sunday.

My early Eagles vs. Packers predictions are expecting a lower-scoring game while backing Philadelphia as a short road underdog. 

Here are my NFL picks for this Monday Night showdown. 

Eagles vs Packers predictions

Here are our early thoughts on the spread and total for this week’s game. We will have a full game preview (with a best bet and SGP) later in the week.

Early MNF spread pick: Eagles +2.5

-110 at bet365

The Philadelphia Eagles are 6-2 and won back-to-back games before going on their bye in Week 9. The week off should have allowed superstar running back Saquon Barkley and No. 1 wide receiver A.J. Brown to recover from niggling injuries.

Philadelphia's offense is trending in the right direction. Jalen Hurts has completed 71.1% of his passes for 1068 yards with 10 touchdowns and one pick over the last four games. Meanwhile, Barkley finally broke out with 150 rushing yards in Week 8. 

The Green Bay Packers were 13.5-point favorites last week but ended up falling 16-13 to the Panthers. They lost tight end Tucker Kraft to a season-ending injury in that game, which is yet another blow to a banged-up receiver group. 

Quarterback Jordan Love has been trying to do too much, which has resulted in holding on to the ball too long and some bad throws.

With so many of his top targets sidelined, he'll have a tough time throwing against a Philly D that is fourth in the league in opponent pass rating. Especially with the Eagles bolstering their pass rush by trading for Jaelen Phillips.

Early MNF total pick: Under 44.5

-110 at bet365

With the season-ending injury to Kraft, Jayden Reed on the IR, and rookie wideout Matthew Golden dealing with a shoulder injury, Green Bay's offense will have a tough time moving the ball through the air.

That said, the Packers have a strong pass defense themselves, ranking eighth in the league in defensive dropback success rate. They are allowing just 16.3 ppg at home, and even in last week's upset loss to the Panthers, their defense showed up. 

These teams will have to lean on their rushing attacks if they want to move the chains on Monday. That will be even more emphasized in a cold-weather game with temperatures expected to be close to freezing at Lambeau. 

Both offenses play at a slow tempo, with Green Bay 26th in the league in seconds per play and Philadelphia 30th. That sluggish pace and a reliance on running the ball should lead to the clock getting chewed up and the Under cashing. 

Eagles vs Packers odds

  • Eagles vs. Packers spread: Packers -2.5
  • Eagles vs. Packers moneyline: Eagles +115, Packers -135
  • Eagles vs. Packers Over/Under: 44.5

How to watch Eagles vs Packers

  • Eagles vs. Packers matchup
  • Date: Monday, November 10, 2025, 8:15 p.m. ET
  • City: Green Bay, WI
  • Venue: Lambeau Field
  • TV: ESPN & ABC

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Rohit Ponnaiya
Betting Analyst

With a background playing soccer, rugby, and boxing, combined with a journalism degree, it's little surprise that Rohit gravitated towards the world of sports betting. He specializes in betting on UFC and college basketball, two sports where the eyeball test can tell you a lot more about matchups than analytics. Rohit has years of experience handicapping NFL and NBA games as well as niche betting markets such as politics. He's also the resident CFL expert and formerly hosted "The Chez and Ro Show" with former CFL star Davis Sanchez.

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