Game 2 of the 2025-26 NFL season pits the Kansas City Chiefs against the Los Angeles Chargers at Corinthians Arena in Sao Paulo, Brazil. Kickoff is at 8:00 p.m. ET on YouTube.
Our Chiefs vs. Chargers predictions tell you where to place your last-minute spread, total, and player prop bets on Friday, September 5.
Chiefs vs Chargers FNF predictions
- Chiefs -3 (-115)
- Under 46.5 (-110)
- Worthy anytime TD (+130)
- Herbert o226.5 pass yds (-110)
Chiefs vs Chargers FNF best bets
Chiefs -3
Jason Logan will put his faith in Patrick Mahomes and Andy Reid to once again get the better of their AFC West rivals.
"We don’t often see the combo of Justin Herbert and Jim Harbaugh outmatched, but Patrick Mahomes and Andy Reid have had L.A.’s number. Kansas City is 11-3 SU versus the Chargers since 2018."
Under 46.5
Logan sees few explosive plays taking place in Brazil tonight, hence his siding with the Under.
"The Chargers could have success running the ball, which means short gains with the clock ticking. The Chiefs are missing pieces of this passing game and lack explosive plays. I liked the Under at 45.5 and even more now that we’ve seen this climb to 46.5 O/U. I’m wondering how bad the field will be in Brazil after last year’s terrible turf."
Chiefs vs Chargers FNF TD picks
Xavier Worthy anytime TD
Rohit Ponnaiya likes the chances of Xavier Worthy finding the end zone for K.C. this evening.
"Worthy proved that his game speed was just as impressive as his track speed by scoring 12 TDs in the regular season and playoffs. Offensive coordinator Matt Nagy was creative in getting the ball in the receiver's hands, which resulted in Worthy getting 20 rush attempts for 104 yards and three scores. No Chiefs wide receiver saw more targets in the red zone than Worthy, who hauled in 11 of 18 throws."
Chiefs vs Chargers FNF props
Justin Herbert Over 226.5 passing yards
Neil Parker predicts plenty of passes, and yardage, for Justin Herbert in this spot.
"Los Angeles Chargers quarterback Justin Herbert has passed for 236+ yards in seven of nine games against the Chiefs, and he also aired it out for a career-high 7.7 yards per attempt last season."
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Chiefs vs Chargers odds
Chiefs vs Chargers game info
| Location | Corinthians Arena, São Paulo, Brazil |
| Date | Friday, September 5, 2025 |
| Kickoff | 8:00 p.m. ET |
| TV | YouTube |
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