The Los Angeles Chargers have won six of their past seven to climb to 10-4 ahead of a date with the 6-7-1 Dallas Cowboys at AT&T Stadium on Sunday, December 21.
My top NFL picks and Chargers vs. Cowboys predictions are calling for the good times to rolling for Los Angeles with the Bolts handing Dallas a third consecutive loss in this Week 16 showdown.
Chargers vs Cowboys prediction
Chargers vs Cowboys Best bet: Chargers moneyline (+112)
The Los Angeles Chargers have consecutive outright wins as an underdog, while the Dallas Cowboys have lost outright in back-to-back games as a favorite.
Los Angeles has also won six of seven to improve to 10-4 for the campaign, and Dallas is all but officially eliminated from the postseason at 6-7-1.
Additionally, just when it looked like the Dallas defense might be turning the corner, the Cowboys have given up 78 points while allowing the fourth-highest EPA per play the past two weeks.
Dallas now sits 30th in defensive DVOA while allowing the third-highest EPA per play and second-most points per game (30.0). And, for comparison, Los Angeles ranks ninth in defensive DVOA while allowing the fifth-lowest EPA per play and ninth-fewest points per game.
I also value the Chargers averaging the second-longest drive time for the season, while also dominating the time of possession in three consecutive games. The Bolts rushed 110 times alongside quarterback Justin Herbert’s 75 passing attempts during the 3-0 surge out of their Week 12 bye.
Keeping the Dallas offense on the sidelines with clock-churning drives to avoid a road shootout will be priority No. 1 for Chargers head coach Jim Harbaugh, and it’s a recipe for pulling off the upset Sunday afternoon at AT&T Stadium.
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Chargers vs Cowboys same-game parlay
Bolts back Omarion Hampton has cleared this total in consecutive games since returning to action, and he’s totaled a respectable 117 yards on 28 carries for 4.2 per tote.
Additionally, backfield mate Kimani Vidal has been held to 3.0 yards per carry across his 26 touches the past two weeks.
The matchup also checks out.
Dallas has allowed the fourth-highest EPA per rush and rushing success rate while ranking 28th in PFF run defense grade and 29th in run defense DVOA, after all.
Add the Cowboys allowing 15 touchdowns to opposing running backs through 14 games, and I also like Hampton to find paydirt Sunday.
Chargers vs Cowboys SGP
- Chargers moneyline
- Omarion Hampton Over 47.5 rushing yards
- Omarion Hampton anytime touchdown
Our big-ticket SGP: Pickens picks it up
Cowboys receiver George Pickens has been quiet the past two weeks with just eight receptions for 70 yards, so I’m expecting a rebound game and trip to the end zone for TD No. 9 of the year.
Chargers vs Cowboys SGP
- Chargers moneyline
- Omarion Hampton Over 47.5 rushing yards
- Omarion Hampton anytime touchdown
- George Pickens anytime touchdown
Chargers vs Cowboys odds
- Spread: Los Angeles +2.5 (-112) | Dallas -2.5 (-108)
- Moneyline: Los Angeles +112 | Dallas -132
- Over/Under: Over 49.5 (-115) | Under 49.5 (-105)
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Chargers vs Cowboys trend to know
The Los Angeles Chargers have won six of their past seven games. Find more NFL betting trends for Chargers vs. Cowboys.
How to watch Chargers vs Cowboys
| Location | AT&T Stadium, Arlington, TX |
| Date | Sunday, December 21, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | FOX |
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