South Carolina and Missouri meet in the Show-Me State in a conference battle tonight.
The Tigers will be looking to build an early-season playoff résumé, while the Gamecocks will be hoping to rebound from a humiliating loss to Vanderbilt.
My South Carolina vs. Missouri predictions break it all down as I bring you my college football picks for Saturday, September 20.
Kickoff is set for 7:00 p.m. ET from Memorial Stadium in Columbia, with the game airing on ESPN.
South Carolina vs Missouri prediction
South Carolina vs Missouri best bet: Kevin Coleman longest reception Over 25.5 yards (-115)
This South Carolina secondary struggling is probably the thing I’m most convinced about in a game full of uncertainties.
Enter Kevin Coleman. The senior has bounced around a few schools during his time in college, but he has started his final year at Missouri very strongly.
I’ll back him to exceed this longest reception number for a variety of reasons.
The speedster eclipsed this number easily in the one truly competitive game that Missouri has played this season with a 50-yard catch against Kansas.
He’s back in his home state and has filled a big void left by Luther Burden’s departure nicely so far. I expect something similar in this matchup, given the struggles South Carolina has had against explosive passing plays.
It’s a little shocking for an SEC team with such high preseason praise, but coming into this matchup, the Gamecocks rank in the bottom 4th percentile in pass explosiveness allowed.
Almost 14% of the completed passes against them have been classified as explosive or passes of more than 20 yards.
With a number nearly in that range and Coleman displaying just how dangerous he can be downfield, this is an easy play.
South Carolina vs Missouri same-game parlay
I projected this spread closer to 13, even with healthy Sellers, so I’ll take Missouri to cover.
I’ll also go ahead and grab the Under for reasons noted above, like a fairly slow tempo from both teams.
South Carolina vs Missouri SGP
- Kevin Coleman longest reception Over 25.5 yards
- Missouri -10.5
- Under 48.5
Our deep-ball SGP: Take It To The House
We added Beau Pribula to go over his passing total, a play directly correlated to our best bet above.
He’s exceeded this number in two of his three starts this season, and I expect that to continue here against a defense that struggles against the big play.
Lastly, we finished with Rahsul Faison to find the end zone. I expect him to get an increased amount of volume with Sellers banged up.
South Carolina vs Missouri SGP
- Kevin Coleman longest reception Over 25.5 yards
- Missouri -10.5
- Under 48.5
- Beau Pribula Over 231.5 passing yards
- Rahsul Faison anytime TD
South Carolina vs Missouri game predictions
South Carolina vs Missouri moneyline prediction: Missouri
The Tigers have shown themselves to be the more well-rounded team, and being at home doesn’t hurt either. They’ll win the game.
South Carolina vs Missouri spread prediction: Missouri -10.5
Missouri is the slight lean here because of its consistent offense, top-20 efficiency across passing and rushing, and multiple paths to winning, while South Carolina’s offense is limited and unlikely to keep up if it falls behind.
South Carolina vs Missouri Over/Under prediction: Under 48
Even with Missouri’s offensive edge, South Carolina’s run-heavy, clock-draining approach, plus Missouri’s tendency to slow things down with a lead, point toward the Under.
South Carolina vs Missouri odds
- Spread: South Carolina +9.5 (-110) | Missouri -9.5 (-110)
- Moneyline: South Carolina +260 | Missouri -330
- Over/Under: Over 48.5 (-110) | Under 48.5 (-110)
South Carolina vs Missouri trend to know
Missouri has covered the spread in 10 of its last 13 games (+6.60 Units / 46% ROI). Find more college football betting trends for South Carolina vs Missouri.
How to watch South Carolina vs Missouri
| Location | Memorial Stadium, Columbia, MO |
| Date | Saturday, September 20, 2025 |
| Kickoff | 7:00 p.m. ET |
| TV | ESPN |
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