The No. 4 Oregon Ducks are heavily favored to start 3-0 on the season when they visit the 1-1 Northwestern Wildcats on Saturday, September 13. "Big Noon Kickoff" comes your way on FOX today.
Our Oregon vs. Northwestern predictions and college football picks see Ducks QB Dante Moore piling up the passing yards.
Oregon vs Northwestern prediction
Oregon vs Northwestern best bet: Dante Moore Over 235.5 passing yards (-114)
Oregon Ducks quarterback Dante Moore enters Week 3 coming off an impressive start to the season.
In Week 1 against Montana State, he threw for 213 yards and three touchdowns, then followed that with 266 yards and three more scores versus Oklahoma State.
The Northwestern Wildcats' defense allows a stingy 152 passing yards per game, but they haven’t faced a dynamic and explosive offense, and Moore has a wealth of wideouts to throw to.
Moore is accurate, and his efficient decision-making powers this Oregon offense. I expect Moore to target multiple wideouts and backs consistently enough to move the chains, making 236+ passing yards a realistic expectation in this matchup.
Oregon vs Northwestern same-game parlay
Malik Benson has already hauled in two scoring strikes, and another is in the cards. That should help lead to an Oregon victory by at least 28 points.
Oregon vs Northwestern 3-leg SGP
- Dante Moore Over 235.5 passing yards
- Malik Benson anytime TD
- Oregon -27.5
Our deep-ball SGP: Moore the merrier
- Moore has thrown 3+ TD passes in both games this season.
- Dakorian Moore is coming off a 69-yard receiving game against Oklahoma State.
- Preston Stone helps the Wildcats avoid a shutout.
Oregon vs Northwestern 6-leg SGP
- Dante Moore Over 235.5 passing yards
- Malik Benson anytime TD
- Oregon -27.5
- Dante Moore Over 2.5 TD passes
- Preston Stone Over 0.5 TD passes
- Dakorien Moore Over 43.5 receiving yards
Oregon vs Northwestern game predictions
Oregon vs Northwestern moneyline prediction
Oregon has too much on both sides of the ball and shouldn’t have any trouble beating the Wildcats.
Oregon vs Northwestern spread prediction
The Ducks' offense is too potent for the Wildcats. Moore is more than capable of putting up gaudy numbers, and he has enough versatile weapons to hurt Northwestern enough to win by at least four touchdowns.
Oregon vs Northwestern Over/Under prediction
I believe this game will go Over the total. Oregon can light up the scoreboard in numerous ways, while Northwestern should do its part offensively to send this game Over 48.5.
Oregon vs Northwestern odds
- Spread: Oregon -27.5 (+100) | Northwestern +27.5 (-122)
- Moneyline: Oregon -7000 | Northwestern +2000
- Over/Under: Over 48.5 (-112) | Under 48.5 (-108)
Oregon vs Northwestern trend to know
Oregon has hit the moneyline in 13 of their last 14 games (+12.50 Units / 5% ROI). Find more college football betting trends for Oregon vs Northwestern.
How to watch Oregon vs Northwestern
| Location | Northwestern Medical Field at Martin Stadium, Evanston, IL |
| Date | Saturday, September 13, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | FOX |
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