The top-ranked Ohio State Buckeyes travel cross-country to Seattle for a Week 5 showdown with the Washington Huskies. It marks the Big Ten opener for both unbeaten teams, setting up a highly anticipated clash.
Find out why my Ohio State vs. Washington predictions and college football picks for Saturday, September 27 are focused on true freshman running back Bo Jackson’s rushing yards prop.
Ohio State vs Washington prediction
Ohio State vs Washington best bet: Bo Jackson Over 45.5 rushing yards (-114)
It’s a new-look offense in Columbus this season as the Ohio State Buckeyes break in a new quarterback and running back to pair with their elite wide receiving corps.
Although it’s been a three-headed monster in the backfield, true freshman running back Bo Jackson has been by far the most productive of the bunch, earning his fair share of touches entering Big Ten play.
Jackson is averaging a robust 12.1 yards per carry, turning 18 carries into 217 yards and a touchdown. After not receiving a touch in the opener against Texas, he’s gone over the century mark in consecutive games.
When the offense stalled out in a too-close-for-comfort game against Ohio last time out, it was Jackson who ignited the offense. His contributions won’t go overlooked, and the precocious back will be given a workload on the road against a challenging Washington Huskies squad.
Washington has been softer against the rush than the pass for several years now. The Huskies haven’t yet faced an offense to truly test them on the ground, but the underlying numbers (118th in PFF’s rush defense grade) indicate that things may not be totally fixed. I’ll bet on Jackson capitalizing.
Ohio State vs Washington same-game parlay
Traveling across the country is a difficult task for any team, even if you’re the reigning defending champs. Washington is a tough conference opponent, and Husky Stadium is a difficult place to play, so I’ll bank on Demond Williams & Co. keeping things relatively close against a quarterback making his first true road start.
Ohio State represents by far the toughest challenge Washington’s offense has seen, and both teams play at a slow tempo (Ohio State 131st, Washington 85th), so I don’t envision this one turning into a shootout.
Ohio State vs Washington 3-leg SGP
- Bo Jackson Over 45.5 rushing yards
- Washington +8.5
- Under 52.5
Our deep-ball SGP: Jonah wails on Buckeyes
Running back Jonah Coleman has been a force both on the ground (347 rushing yards, nine touchdowns) and in the air (150 receiving yards, one touchdown), and he should receive a heavy workload as the Huskies look to pull off the upset.
Ohio State vs Washington SGP
- Bo Jackson Over 45.5 rushing yards
- Washington +8.5
- Under 52.5
- Jonah Coleman Over 18.5 receiving yards
Ohio State vs Washington game predictions
Ohio State vs Washington moneyline prediction
Ohio State will move to 4-0. Defense travels, and the Buckeyes’ defense is the best unit in this game.
Ohio State vs Washington spread prediction
Washington will cover this spread as they’re a tough out at home, where they carry a 22-game winning streak.
Ohio State vs Washington Over/Under prediction
This game will stay Under the total because both teams play at a slow tempo, Ohio State has an elite defense, and Julian Sayin is making his first true road start.
Ohio State vs Washington odds
- Spread: Ohio State -8.5 | Washington +8.5
- Moneyline: Ohio State -320 | Washington +255
- Over/Under: Over 52.5 | Under 52.5
Ohio State vs Washington trend to know
Jonah Coleman has recorded more than 18.5 receiving yards in five consecutive games. Find more college football betting trends for Ohio State vs Washington.
How to watch Ohio State vs Washington
| Location | Husky Stadium, Seattle, WA |
| Date | Saturday, September 27, 2025 |
| Kickoff | 3:30 p.m. ET |
| TV | CBS |
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Odds are correct at the time of publishing and are subject to change.
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