Missouri State vs New Mexico State Prediction, Picks & Odds for Tonight — College Football Week 9

With New Mexico State refocusing on its ground attack, Logan Fife won’t be asked to air it out as often as he did earlier in the season. Missouri State’s deliberate pace should also limit Fife’s total passing opportunities.

JD Yonke - Betting Analyst at Covers.com
JD Yonke • Betting Analyst
Oct 22, 2025 • 17:36 ET • 4 min read

NCAAF

Match starts: 12 mins
NMSU
64 %
MOSU
36 %
Read Analysis
Logan Fife New Mexico State Aggies NCAAF
Photo By - Imagn Images. Aggie quarterback Logan Fife (4) looks over the defense as NMSU took on the University of Tulsa Golden Hurricane.

The Missouri State Bears travel to Las Cruces for a Wednesday night clash with the New Mexico State Aggies in Week 9.

Both teams enter at 3-3, setting the stage for a tight matchup, with the Bears currently favored by 1.5 points on the road.

I’m targeting NMSU quarterback Logan Fife’s passing yardage prop with my Missouri State vs. New Mexico State predictions and college football picks for Wednesday, October 22.

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Missouri State vs New Mexico State prediction

Missouri State vs New Mexico State best bet: Logan Fife Under 263.5 passing yards (-114)

One storyline from the New Mexico State Aggies’ last two games is the emergence of the running game. After posting an abysmal 39.5 rushing yards per game in their first four contests (which drops to 26.7 if you exclude the FCS game), the Aggies have accumulated 241 yards and three scores on the ground in their first two conference games. 

The offense erred extremely pass-happy to start the year, but that should balance out now that running back Kadarius Calloway and the ground game have gotten going. That leads us to quarterback Logan Fife’s passing yardage prop, which is set at 263.5.

This line is high for two reasons — NMSU has a high pass rate (58.1%), and the Missouri State Bears grade out poorly against the pass (121st in EPA per pass, 125th in passing success rate allowed). I’ve explained the former, and the latter is inflated due to matchups against USC (second in EPA per pass), SMU (24th), and Western Kentucky (seventh in pass rate). 

The Bears have been effective otherwise. Fife has gone Under this number in five of his six outings, so here’s betting on another.

Missouri State vs New Mexico State same-game parlay

I also fancy Fife’s passing yardage Under because Missouri State plays at a snail’s pace, posting the fewest snaps per minute of any team in the country. That should also lead to a lower-scoring game against a defensively stout NMSU team (26th in EPA per play) that labors on offense (119th).

The Aggies dominated Sam Houston (37-10) and outgained Liberty (+95 in total yardage) in CUSA play, whereas Missouri State was outgained by Western Kentucky (-62) and lowly Middle Tennessee State (-5). Give me the Aggies at home.

Missouri State vs New Mexico State SGP

  • Logan Fife Under 263.5 passing yards
  • Under 51.5
  • New Mexico State +1.5

Our deep-ball SGP: It's all Aggies

Donovan Faupel has double the targets (45) of any other NMSU wide receiver and has found the end zone twice this season, so his anytime touchdown prop correlates nicely with an Aggies cover.

Missouri State vs New Mexico State SGP

  • Logan Fife Under 263.5 passing yards
  • Under 51.5
  • New Mexico State +1.5
  • Donovan Faupel anytime touchdown

Missouri State vs New Mexico State game predictions

Missouri State vs New Mexico State moneyline prediction

New Mexico State will win this game at home, as it's been the more impressive squad since C-USA play began.

Missouri State vs New Mexico State spread prediction

New Mexico State will cover the spread against a Missouri State team with a poor defense (128th in EPA per play) and an offense that struggles to move the ball consistently (117th in success rate).

Missouri State vs New Mexico State Over/Under prediction

These are two of the worst blocking teams in the country (both rank bottom two in stuff rate), and Missouri State plays at the slowest pace in the country, so this game will stay Under the total.

Missouri State vs New Mexico State odds

  • Spread: Missouri State -1.5 | New Mexico State +1.5
  • Moneyline: Missouri State -118 | New Mexico State +100
  • Over/Under: Over 51.5 | Under 51.5

Missouri State vs New Mexico State trend to know

Logan Fife has thrown for fewer than 263.5 passing yards in five of six games. Find more college football betting trends for Missouri State vs New Mexico State.

How to watch Missouri State vs New Mexico State

Location Aggie Memorial Stadium, Las Cruces, NM
Date Wednesday, October 22, 2025
Kickoff 9:00 p.m. ET
TV CBSSN

Missouri State vs New Mexico State latest injuries

Missouri State vs New Mexico State weather

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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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JD Yonke
Betting Analyst

JD is a diehard college football fan with five years of experience writing betting and fantasy content for publications such as SportsGrid, Fantasy Points, Fantrax, and Devy Watch. An avid reader, he uses his inclination to look at things with an exhausting and in-depth, analytic viewpoint combined with a love for statistics and metrics to form a well-rounded handicapping approach.

e's an integral member of the niche (but growing!) college fantasy football community, twice traveling to Canton, OH for the Fantasy Football Expo as a member of the CFF King's Classic drafting squad. His specialization in college football DFS and prop betting taught him that there are exploitable markets to be found and that narrowing your focus is integral to being a profitable bettor.

A lifelong Californian who grew up playing baseball, basketball, football, and lacrosse, he's glad to share a passionate love for sports with this wonderful community.

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