The LSU Tigers will try to put all the noise behind them in Week 8 as they travel to face the Ole Miss Rebels, who are coming off a signature win against Tennessee last week.
LSU is also coming off a big win over Florida but following that triumph, it was announced that head coach Ed Orgeron would no longer coach the team beyond this season.
For the second straight week, LSU opened as a two-possession college football betting underdog. The Tigers won last week — can they find a way to cover (or even win) against Ole Miss on the road?
Find out in our free picks and predictions for LSU vs. Ole Miss on Saturday, October 23, 3:30 pm ET.
LSU vs Ole Miss odds
Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.
The Tigers opened as a 10.5-point underdog, but the spread has actually shifted in favor of LSU, which sits at +9.5 at the time of writing. Meanwhile, the total opened at 75.5 and has ticked up to 77. Use the live odds widget above to track any future line movements right up until kickoff and be sure to check out the full college football odds before placing your bets.
LSU vs Ole Miss picks
Picks made on 10/21/2021 at 7:56 p.m. ET.
Click on each pick to jump to the full analysis.
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LSU vs Ole Miss game info
• Location: Vaught-Hemingway Stadium, Oxford, MS
• Date: Saturday, October 23, 2021
• Time: 3:30 p.m. ET
• TV: CBS
LSU vs Ole Miss betting preview
Be sure to monitor the gametime conditions with our NCAA football weather info.
LSU: Andre Anthony DE (Out), Kayshon Boutte WR (Out), John Emery Jr. (Out), Major Burns CB (Questionable), Ali Gaye DE (Questionable), Glen Logan DE (Out), Eli Ricks CB (Out), Deion Smith WR (Questionable), Derek Stingley Jr. CB (Out), Devonta Lee (Questionable), Brian Thomas Jr. (Questionable).
Ole Miss: Matt Corral QB (Doubtful), Braylon Sanders WR (Questionable).
Find our latest NCAA football injury reports.
Betting trend to know
The Tigers are 5-1 ATS in their last six games after allowing more than 40 points in their previous game. Find more NCAA betting trends for LSU vs. Ole Miss.
LSU vs Ole Miss predictions
LSU +9.5 (-112)
LSU has been rocked by injuries this year, leaving the defense to basically play its second team while the offense has secondary choices at quarterback, running back, and receiver. Meanwhile, Ed Orgeron is officially a lame duck and will not return next year as head coach.
And despite all of that, we like the Tigers to start a winning streak after defeating Florida last week. The LSU defense has still done very well in coverage and forced multiple turnovers last week against the Gators. On offense, Max Johnson finally got some help from the rushing game, as Tyrion Davis-Price ran for 287 yards on 36 carries and scored three touchdowns.
It seems as though LSU finally figured out its running game and that’s going to be huge against an Ole Miss defense that is allowing 196.3 yards per game on the ground. Ole Miss has been awful stopping the run and now LSU has some swagger in the ground game.
Adding to our LSU love is that Heisman Trophy co-favorite Matt Corral is doubtful for this game. Ole Miss' star signal-caller has thrown 14 touchdowns against just one interception all year long, with 450 rushing yards and eight scores on the ground as well. However, Corral ran the ball 30 times last week and, after that physical beating, has been downgraded to doubtful this week with an unspecified injury.
If Corral does indeed sit, the next man up is true freshman Luke Altmyer. He’s got a smooth throwing action but is scouting reports say he's mainly a pocket passer. That's good for LSU, which has only really struggled against mobile, dual-threat quarterbacks this season.
Look for LSU to take advantage of a true freshman and force some takeaways to cover this spread. We wouldn’t be surprised if LSU wins this game outright with Corral out... yet it's almost a double-digit underdog?
Under 77 (-110)
So many things need to happen correctly for this game to go over. With Corral officially doubtful for this game, we're not going to sit here and take an Over 77 with a true freshman set to take the field.
The Tigers will get theirs offensively, but the LSU defense has shown signs of improvement as the season progresses. It's a young group that will make mistakes at times but has plenty of skill, especially in the secondary — even without Derek Stingley Jr. and Eli Ricks.
Don’t underestimate this Tigers defense and what it's capable of against a true freshman quarterback that can’t scramble out of the pocket like Corral can.
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