We have a crucial C-USA mid-week matchup to consider when the Delaware Blue Hens visit the Jacksonville State Gamecocks.
The Blue Hens are slight favorites, but my Delaware vs. Jacksonville State predictions expect the home team to come out on top.
Read on for my college football picks for Wednesday, October 15.
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Delaware vs JSU prediction
Delaware vs JSU best bet: Jacksonville State moneyline (+124)
The Jacksonville State Gamecocks look poised to notch another home win behind a relentless running attack and national rushing leader Cam Cook.
Jacksonville State averages nearly 280 yards per game on the ground, and Cook’s power and breakaway speed have overwhelmed every defense he’s faced.
Cook and the Gamecocks' physical dominance should continue against a Delaware Blue Hens defensive group that allows 154 rushing yards per game and 64 plays of 10+ yards.
It’s Delaware’s vulnerability against explosive, potent offenses that should lead Jacksonville State to victory.
Delaware has been world-beaters as the underdog, but has lost both times as a favorite, and meets a Jacksonville State group that’s undefeated at home.
Cook and the Gamecocks are coming off a well-earned road victory over Sam Houston. A victory tonight keeps Jacksonville State in the C-USA championship hunt, and I’m betting they beat Delaware.
Delaware vs JSU same-game parlay
Jacksonville State has cleared its team total in four of five, while Delaware has allowed 28+ points in three of its previous four games.
This should stay Under the total because Jacksonville State’s run-heavy style shortens games. At the same time, Delaware’s pass-heavy attack faces a Gamecocks defense capable of generating pressure and limiting big passing plays.
Delaware vs JSU SGP
- Jacksonville State moneyline
- Jacksonville State team total Over 27.5
- Under 57.5
Our deep-ball SGP: Home Cook-ing
Cam Cook has scored multiple touchdowns in two of his last three games and three times this season.
Freshman quarterback Caden Creel has one touchdown scamper in each of his previous three games.
Delaware vs JSU SGP
- Jacksonville State moneyline
- Jacksonville State team total Over 27.5
- Under 57.5
- Cam Cook 2+ touchdowns
- Caden Creel anytime touchdown
Delaware vs JSU odds
- Spread: Delaware -2.5 (-120) | JSU +2.5 (-102)
- Moneyline: Delaware -146 | JSU +124
- Over/Under: Over 57.5 (-112) | Under 57.5 (-108)
Delaware vs JSU trend to know
Jacksonville State has hit the moneyline in five of its last six games at home (+4.95 Units / 20% ROI). Find more college football betting trends for Delaware vs JSU.
How to watch Delaware vs JSU
| Location | AmFirst Stadium, Jacksonville, AL |
| Date | Wednesday, October 15, 2025 |
| Kickoff | 7:00 p.m. ET |
| TV | ESPN |
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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