March Madness Moneyline Picks for Friday, March 20

Phil Naessens - Contributor at Covers.com
Phil Naessens • Betting Analyst 19+ years betting experience
Updated: Mar 19, 2026 , 10:00 PM ET • 4 min read

We're in for 16 more Round 1 games on Friday, and Phil Naessens has delivered a moneyline pick for all of them.

Florida Gators guard Xaivian Lee (1) reacts after a made three point basket against the Vanderbilt Commodores during the second half at Bridgestone Arena.
Photo By - Reuters Connect. Florida Gators guard Xaivian Lee (1) reacts after a made three point basket against the Vanderbilt Commodores during the second half at Bridgestone Arena.

The annual rite of passage, also known as March Madness, resumes Friday with 16 first-round NCAA Division 1 tournament games.

While the remaining first-round outcomes are mostly a foregone conclusion, I believe I have found solid college basketball moneyline plays for you to consider.

Read on for my March Madness picks for Thursday, March 20. 

March Madness moneyline picks on Friday, March 20

Matchup Pick
Santa Clara Santa Clara
vs
Kentucky Kentucky
Santa Clara +125
Akron Akron
vs
Texas Tech Texas Tech
Akron +250
Duke LIU
vs
Arizona Arizona
Arizona -100000
Missouri Wright State
vs
Virginia Virginia
Virginia -2500
Missouri Tennessee State
vs
Iowa State Iowa State
Iowa State -1000
Missouri Hofstra
vs
Alabama Alabama
Alabama -850
Utah State Utah State
vs
Villanova Villanova
Utah State -120
Miami (Ohio) Miami (OH)
vs
Tennessee Tennessee
Tennessee -650
Iowa Iowa
vs
Clemson Clemson
Iowa -135
Missouri Northern Iowa
vs
St. John's St. John's
St. John's -550
UCF UCF
vs
UCLA UCLA
UCLA -240
Texas A&M Queens University
vs
Purdue Purdue
Purdue -10000
Prairie View A&M Prairie View A&M
vs
Florida Florida
Florida -100000
Missouri California Baptist
vs
Kansas Kansas
Kansas -1200
Missouri Furman
vs
UConn UConn
UConn -5000
Missouri Missouri
vs
Miami Miami
Miami -125

Lines courtesy of bet365.

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Expert March Madness Round 1 moneyline picks for Thursday

No. 10 Santa Clara vs No. 7 Kentucky: Santa Clara Santa Clara (+125)

The Santa Clara Broncos average 82.9 points per game, shoot efficiently, and take care of the ball. The Kentucky Wildcats foul too much, don’t force mistakes, and lack the defense to disrupt that.

This sets up a free-throw-heavy track meet that Santa Clara is equipped to win. 

No. 12 Akron vs No. 5 Texas Tech: Texas Tech Texas Tech (+250)

The Texas Tech Red Raiders' perimeter defense has slipped without JT Toppin, allowing teams to shoot over 33% on 20+ attempts from downtown in six games without him.

If the Akron Zips get those looks, they can pull off the upset as they defend well enough to slow Tech’s elite 3-point shooting. 

No. 16 LIU vs No. 6 Arizona: Arizona Arizona (-100000)

The LIU Sharks may have devoured the NEC conference, but the Arizona Wildcats swim in deeper waters. They're elite on both ends of the hardwood, and the depth of this Arizona team means trouble for LIU from wire-to-wire.  

No. 14 Wright State vs No. 5 Virginia: Virginia Virginia (-2500)

The Wright State Raiders' below-average defense means they need to score to win. That will be problematic against the Top 20 Virginia Cavaliers defense. I expect Virginia to flex its defensive muscles and its vastly improved offense rolls to victory.  

No. 15 Tennessee State vs No. 2 Iowa State: Iowa State Iowa State (-1000)

Despite the Iowa State Cyclones recent scoring woes, they have an extremely winnable March Madness matchup with the Tennessee State Tigers.

The Tigers like to get up and down the floor, but they face an elite Cyclones defense that they can’t hurt enough to pull off the upset. 

No. 13 Hofstra vs No. 4 Alabama: Alabama Alabama (-850)

Second-leading scorer Aden Holloway’s absence will hurt the Alabama Crimson Tide down the road, but they're deep enough to beat the Hofstra Pride. Hofstra likes to get physical, but Alabama has the bigger bodies and will win. 

No. 9 Utah State vs No. 8 Villanova: Utah State Utah State (-120)

The Villanova Wildcats struggled against top competition, going just 2-8 in Quadrant 1 games, and their defense ranks outside the Top 150 against both 2- and 3-point shooting.

The Utah State Aggies' efficient offense should exploit that, and shooting 49% from the field and 35% from three is how they beat the Wildcats.

No. 11 Miami (OH) vs No. 6 Tennessee: Tennessee Tennessee (-650)

The Miami (OH) RedHawks live off clean long-range looks, but the Tennessee Volunteers' defense is built to stop that. The Volunteers dominate the glass, and Miami’s lack of rebounding and interior defense will finally be exposed. 


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No. 9 Iowa vs No. 8 Clemson: Iowa Iowa (-135)

This projects as a slow, physical battle, the exact type of game where Clemson Tigers center Carter Welling is missed most. His rebounding and interior defense matter here, and without him, Clemson will struggle in the paint against a very solid Iowa Hawkeyes group.

No. 12 Northern Iowa vs No. 5 St. John's: St. John's St. John's (-550)

The Northern Iowa Panthers play at a slow pace, pack the paint, and force opponents to win from the perimeter. The St. John’s Red Storm brings the stronger defense, and Zuby Ejiofor’s physical presence inside gives them a reliable edge Northern Iowa will struggle to contain.

No. 10 UCF vs No. 7 UCLA: UCLA UCLA (-240)

The UCLA Bruins take care of the ball and score efficiently from both inside and outside the arc, giving them a clear offensive edge.

The UCF Knights have dropped four of their last five because of their inconsistent defense, and we’ll look for UCLA to outscore UCF.

No. 15 Queens University vs No. 2 Purdue: Purdue Purdue (-10000)

The Purdue Boilermakers bring a veteran team to St. Louis. They top the NCAA in offensive efficiency and have far too much offensive firepower for the Queens Royals' shaky defense.

Queens likes to push the pace, but Purdue’s above-average defense will get enough stops for the offense to take over.

No. 16 Prairie View A&M vs No. 1 Florida: Florida Florida (-100000)

The Florida Gators overall efficiency and interior scoring should overwhelm the Prairie View A&M Panthers from the start. The Gators dominate the glass, create second chances, and convert at a much higher rate inside.

Prairie View’s poor shooting and limited offensive firepower will make it tough to beat the defending champs. 

No. 13 Cal Baptist vs No. 4 Kansas: Kansas Kansas (-1200)

The California Baptist Lancers have lived off their defense all season. So have the Kansas Jayhawks.

The difference is the Jayhawks' defense is elite against superior competition, and their offense, behind frosh sensation Darryn Peterson, should roll to victory through the Lancers' stop unit. 

No. 15 Furman vs No. 2 UConn: UConn UConn (-5000)

The UConn Huskies offense can be incredibly inconsistent, but they survive off their elite defense, which should thwart anything the offensively inept Furman Paladins can throw at them.

Furman doesn’t take care of the ball, and that won’t fly against a Huskies defense scoring 13 ppg from opponents' turnovers.  

No. 10 Missouri vs No. 7 Miami: Miami Miami (-125)

The Miami Hurricanes have the edge where this game will be decided: turnovers. The Missouri Tigers have committed 12+ turnovers in four straight, and Miami forces nearly 13 per game.

On top of that, Miami ranks second in the ACC in offensive rebounding and first in limiting opponents on the glass. That should be enough for Miami to control this game and win.

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Phil Naessens
Betting Analyst

Prior to joining Covers in 2022, Phil Naessens spent 38 years as a resident tennis pro in Las Vegas, Mykonos, and Corfu, Greece. He’s the past host of the Phil Naessens Show (Armed Forces Radio), and currently hosts the Crush and Rush Tennis Podcast.

Phil is the author of the Betting 101 series (MLB, NFL, NCAAF, and Tennis) and has written for numerous publications, including Advance Local, SB Nation, FanSided, and Lenny Melnick Fantasy Sports. 

His favorite sports to bet on are tennis, MLB, WNBA, Euro men’s and women’s hoops, NCAA sports, NFL, and the NBA. Phil has numerous betting accounts in the US and Europe, and his best advice is to line shop for the best value possible.

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