The Chicago White Sox visit the New York Yankees on Wednesday night for the middle game of a three-game set, with the Yankees listed as -190 home favorites after pummeling Chicago 12-2 in the opener.
Anthony Kay's 4.34 ERA hides a brutal underlying profile that catches up against a Yankees lineup running hot, while Carlos Rodon's contact suppression suffocates a White Sox group still finding production outside its top three bats.
Here are my White Sox vs. Yankees predictions and MLB picks for Wednesday, June 17.
Who will win White Sox vs Yankees today: Yankees -1.5 (+120)
This is one of the bigger ERA-to-expected ERA gaps you'll find this season.
Anthony Kay’s 8.74 expected ERA is concerning, especially paired with a .438 xwOBA allowed and a 58%+ hard-hit rate. Regression is coming, and few teams are better equipped to take advantage of it.
In addition, it's not idea tha a 15% walk rate puts free runners in front of a New York Yankees lineup that I think has found its footing again.
Carlos Rodon counters with a 75th-percentile strikeout rate and 81st-percentile xERA against a Chicago White Sox lineup that strikes out heavily. Play to +100.
COVERS INTEL: Anthony Kay has allowed an average exit velocity of 92.4 mph in 2026, one of the worst marks in baseball
White Sox vs Yankees Over/Under pick: Over 8.5 (-103)
I like the Over to -130.
Anthony Kay's .594 expected SLG allowed and 10.3% barrel rate is a big story. I mentioned how I expect the Yankees to hit him hard and there's just loads of evidence to back that up.
On the other side, Carlos Rodon's bottom 3 percentile walk rate is always a story. It's an issue here because this White Sox team has quietly hung around the top ten of baseball in various hard-hit metrics.
Yankees do the heavily lifting and the White Sox put up a crooked inning in a hitter-friendly stadium.
- ML/RL bets: 29-26, +5.46 units
- Over/Under bets: 34-22, +15.82 units
White Sox vs Yankees odds
- Moneyline: Chicago +155 | New York -190
- Run line: Chicago +1.5 | New York -1.5
- Over/Under: Over 8.5 | Under 8.5
White Sox vs Yankees trend
The New York Yankees have hit the Moneyline in 7 of their last 8 games (+6.10 Units / 63% ROI). Find more MLB betting trends for White Sox vs. Yankees.
How to watch White Sox vs Yankees and game info
| Location | Yankee Stadium, Bronx, NY |
| Date | Wednesday, June 17, 2026 |
| First pitch | 7:05 p.m. ET |
| TV | CHSN, Amazon Prime Video |
| White Sox starting pitcher | Anthony Kay (6-1, 4.34 ERA) |
| Yankees starting pitcher | Carlos Rodon (2-2, 3.19 ERA) |
White Sox vs Yankees latest injuries
White Sox vs Yankees weather
Odds are correct at the time of publishing and are subject to change.
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