The Twins have struggled mightily on the road, posting a 6-12 record to date.
My Twins vs. Guardians predictions expect their woes to continue in a divisional clash with Cleveland.
Let's dive deeper into my MLB picks for Friday, May 8.
Who will win Twins vs Guardians today: Guardians moneyline (-145)
Minnesota Twins prospect Connor Prielipp has posted good results, but there may be some smoke and mirrors. He faced the Blue Jays, Mariners, and Mets — all of whom are under .500 and rank 24th or lower in runs.
He also benefited from luck. Prielipp has induced grounders only 28.6% of the time, very much on the low side. Opponents are also hitting .182 on balls put in play. That is approximately 100 points below where that number should be.
The Cleveland Guardians rank ninth in ISO, 11th in wOBA, and own a BABIP of .292 against left-handed pitchers. They should cause more problems for Prilipp.
COVERS INTEL: Minnesota's bullpen has allowed a league-high .282 batting average this season.
Twins vs Guardians Over/Under pick: Over 7.5 (-110)
Prielipp has allowed multiple runs in each of his first three starts and has yet to pitch more than five innings. He's unlikely to provide much length against a Guardians lineup that hits lefties well.
When he exits, the Twins will have to rely on a bullpen that ranks 29th with a 5.81 ERA.
The Twins have scored in bulk against lefties this season, trailing only the Cubs in runs.
Parker Messick has allowed multiple runs in three of the past four, and 3+ in two of the last three, so the road team should chip in here.
- ML/RL bets: 14-6, +5.53 units
- Over/Under bets: 8-11-1, -4.06 units
Twins vs Guardians odds
- Moneyline: Twins +125 | Guardians -145
- Run line: Twins +1.5 (-170) | Guardians -1.5 (+145)
- Over/Under: Over 7.5 (-110) | Under 7.5 (-110)
Twins vs Guardians trend
The Guardians have hit the moneyline in 22 of their last 35 home games (+6.4 units, +14% ROI). Find more MLB betting trends for Twins vs. Guardians.
How to watch Twins vs Guardians and game info
| Location | Progressive Field, Cleveland, OH |
| Date | Friday, May 8, 2026 |
| First pitch | 7:15 p.m. ET |
| TV | Apple TV |
| Twins starting pitcher | Connor Prielipp (1-0, 3.86 ERA) |
| Guardians starting pitcher | Parker Messick (3-1, 2.40 ERA) |
Twins vs Guardians latest injuries
Twins vs Guardians weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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