Tigers vs Guardians Prediction, Picks & Odds for Today’s MLB Game

Our Tigers vs. Guardians predictions are leaning on Jose Ramirez to get Cleveland out of an offensive slump.

Todd Cordell - Betting Analyst at Covers.com
Todd Cordell • Betting Analyst
Jul 4, 2025 • 11:49 ET • 4 min read
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This article contains predictions for an old game!

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Jose Ramirez Cleveland Guardians MLB
Photo By - Imagn Images. Jose Ramirez heads to the dugout in a recent game.

The Cleveland Guardians are in a healthy rut. They've dropped eight of their last 10 games, including seven straight overall.

They’ll be looking to their best player, Jose Ramirez, to help right the ship against the Detroit Tigers. My Tigers vs. Guardians predictions expect a strong offensive performance from Ramirez, as is usually the case against Detroit.

Let’s break it all down with my July 4 MLB picks.

Tigers vs Guardians prediction

My Tigers vs Guardians best bet: Jose Ramirez Over 1.5 total bases (+105 at bet365)

Jose Ramirez, like the Cleveland Guardians offense as a whole, has gone cold of late, but a matchup with the Detroit Tigers could be just what the doctor ordered to help him get back on track.

Ramirez has torched his AL Central foes over the past year and change, averaging 2.4 bases per game while clearing in 13 of 22 head-to-head meetings. That’s an impressive 59% hit rate.

While Reese Olson is a quality pitcher, he hasn’t made a major league appearance since the middle of May. He also allowed eight hits, four runs, and a couple of long balls spanning 10 minor league innings in rehab starts. There could be some rust as he looks to get back into a rhythm.

Ramirez has performed far better against right-handed pitchers this season. He’s averaged exactly two bases per game in contests featuring a righty starter compared to 1.4 over 25 games against left-handed starters.

Tigers vs Guardians same-game parlay (SGP)

Jose Ramirez Over 1.5 total bases

Colt Keith Over 1.5 total bases

Over 7.5

Colt Keith has hit the ball very well of late, especially on the road. He’s averaged 2.0 total bases over his last 20 away games. Isolating Slade Cecconi’s three most used pitches, Keith is hitting .387 with a .444 wOBA in road games over the last two months.

The Tigers are red-hot at the plate, and their games have averaged 10.5 combined runs over the last 10. If Ramirez and the Guardians can chip in, this game should feature eight or more.

Tigers vs Guardians odds

Tigers vs Guardians live odds

Tigers vs Guardians opening odds

  • Moneyline: Detroit -110 | Cleveland -110
  • Run line: Detroit -1.5 (+145) | Cleveland +1.5 (-170)
  • Over/Under: Over 8 | Under 8

Tigers vs Guardians trend

Jose Ramirez has averaged 2.7 total bases over his last 10 home games against a right-handed starter.  Find more MLB betting trends for Tigers vs. Guardians.

How to watch Tigers vs Guardians and game info

Location Progressive Field, Cleveland, OH
Date Friday, 7-4-2025
First pitch 7:10 p.m. ET
TV FDSN-Detroit, CLEGUARDIANS.tv
Tigers starting pitcher Reese Olson
(4-3, 2.96 ERA)
Guardians starting pitcher Slade Cecconi
(3-3, 3.64 ERA)

Tigers vs Guardians latest injuries

Tigers vs Guardians weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Todd Cordell - Covers
Betting Analyst

Todd Cordell is a data-driven betting analyst. He uses numbers to help identify value across a wide variety of sports, with NHL being his specialty. Shot props, in particular, have proven to be a very fruitful market. Todd has served as a betting analyst in the public sphere for many years, most recently with theScore covering the NHL and MLB.

When not writing about sports betting, Todd stays busy analyzing the New Jersey Devils with a fine-tooth comb for InfernalAccess, his Devils-centric blog. Todd attended Sheridan College and graduated in 2014 with a diploma in print journalism.

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