The Boston Red Sox visit the Houston Astros at Daikin Park again tonight after a nail-biter 7-6 loss on Monday evening.
Dustin May hasn’t had a lot of success this season, and my Red Sox vs Astros predictions expect Houston’s lineup to do damage against the trade deadline acquisition.
Read more for my MLB picks for Tuesday, August 12.
Red Sox vs Astros prediction
Red Sox vs Astros best bet: Dustin May Over 2.5 earned runs (+100 at BetMGM)
The Boston Red Sox acquired Dustin May from the Los Angeles Dodgers at the deadline, adding to their rotation in the hopes of a playoff push. While Boston has been playing a lot better and has a realistic shot at a Wild Card, May isn’t having a banner year.
In his first start with the Red Sox, the right-hander allowed three earned runs to the Kansas City Royals. He’s cashed the Over in earned runs allowed in three of his last four outings, previously giving up four earned runs to Boston while still a member of the Dodgers.
He’s only cashed the Under in earned runs twice in his previous eight appearances.
May’s 4.93 ERA is already unsightly, and he’s been substantially worse on the road, posting a 7.09 mark. The Houston Astros are hitting .269 against him across 26 at-bats, and his struggles will continue in H-Town.
Red Sox vs Astros same-game parlay (SGP)
Dustin May Over 2.5 earned runs
Over 8.5
Christian Walker Over 1.5 total bases
This contest has the recipe to be high-scoring. May isn’t the most reliable hurler, and the Astros aren’t turning to their best starter, either.
Spencer Arighetti is 1-2 in three starts with a 7.43 ERA, allowing five earned runs in each of his last two outings. Boston’s lineup is swinging it well at the moment, too.
Christian Walker is on a roll, cashing the Over in total bases in back-to-back games. He was 1-for-3 with a double and two RBI on Monday and finished 3-for-4 against the New York Yankees with a pair of doubles the day before.
He’s 4-for-10 lifetime versus May.
Red Sox vs Astros odds
Red Sox vs Astros live odds
Red Sox vs Astros opening odds
- Moneyline: Boston +105 | Houston -125
- Run line: Boston +1.5 (-210) | Houston -1.5 (+175)
- Over/Under: Over 8.5 (-120) | Under 8.5 (+100)
Red Sox vs Astros trend
The Boston Red Sox have hit the Game Total Over in 30 of their last 49 away games (+9.93 Units / 18% ROI). Find more MLB betting trends for Red Sox vs. Astros.
How to watch Red Sox vs Astros and game info
| Location | Daikin Park, Houston, TX |
| Date | Tuesday, August 12, 2025 |
| First pitch | 8:10 p.m. ET |
| TV | NESN, SCHN |
| Red Sox starting pitcher | Dustin May (6-8, 4.93 ERA) |
| Astros starting pitcher | Spencer Arrighetti (1-2, 7.43 ERA) |
Red Sox vs Astros latest injuries
Red Sox vs Astros weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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