The St. Louis Cardinals and San Diego Padres meet once again tonight as Michael King looks to get back on track.
However, my Cardinals vs. Padres predictions are targeting St. Louis to capitalize on King's recent struggles with an impressive offenisve display.
Read more in my MLB picks for Tuesday, June 16.
Who will win Padres vs Cardinals today: Cardinals moneyline (-109)
San Diego Padres right-hander Michael King hasn't been his dominant self this season, sporting a 4.30 FIP.
King has compiled a 7.64 xERA and 6.81 FIP across his last two starts while allowing an alarming 2.84 home runs per nine innings. He also owns a 38.6% hard-hit rate during the last month.
The St. Louis Cardinals counter with Andre Pallante, who's allowed a mere 3.2% barrel rate over his last two starts to go along with a solid 3.19 xERA. Pallante has surrendered just 0.77 home runs per nine innings over the last two weeks.
St. Louis should generate offense against King, while Pallante is well positioned to keep a struggling Padres lineup in check.
I'll play this pick up to -130.
COVERS INTEL: The Cardinals have an impressive 48.7% hard hit rate over their last seven games, suggesting this matchup against a struggling King is a perfect spot to keep raking. 
Padres vs Cardinals Over/Under pick: Under 8.5 (-125)
Despite King's recent struggles, he's worked into the sixth inning in three consecutive starts, limiting the amount of bullpen exposure.
San Diego's relief corps has been elite, posting a 2.30 ERA and 3.36 FIP over the last week while allowing just 0.66 home runs per nine innings.
As for St. Louis, Pallante typically pitches into the fifth or sixth inning. While the relief corps owns a 4.46 xERA over the last two weeks, the unit enters extremely well-rested after Dustin May threw a shutout on Monday.
The Padres are batting just .234 over their last six games and own a modest .172 ISO during that stretch.
I'll play this pick up to -140.
- ML/RL bets: 26-21, +2.93 units
- Over/Under bets: 27-19, +3.85 units
Padres vs Cardinals odds
- Moneyline: Padres -100 | Cardinals -104
- Run line: Padres -1.5 (+170) | Cardinals +1.5 (-186)
- Over/Under: Over 8.5 (+113) | Under 8.5 (-117)
Padres vs Cardinals trend
The Padres have hit the Under in 24 of their last 40 games (+6.50 Units / 15% ROI). Find more MLB betting trends for Padres vs. Cardinals.
How to watch Padres vs Cardinals and game info
| Location | Busch Stadium, St. Louis, MO |
| Date | Tuesday, June 16, 2026 |
| First pitch | 7:45 p.m. ET |
| TV | TBS |
| Padres starting pitcher | Michael King (4-5, 3.46 ERA) |
| Cardinals starting pitcher | Andre Pallante (7-4, 3.88 ERA) |
Padres vs Cardinals latest injuries
Padres vs Cardinals weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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