The 2025 edition of Roberto Clemente Day features an abbreviated nine-game slate, but that's more than enough to get in on the action.
All Pittsburgh Pirates players will wear the number 21 in honor of Clemente as they open up the schedule against the Chicago Cubs.
Our MLB picks and moneyline predictions on Monday, September 15, take a look at all nine games, offering the best choices to win each straight up.
MLB moneyline picks for Roberto Clemente Day
| Matchup | Pick |
|---|---|
 Cubs vs  Pirates |
(+100) |
 Braves vs  Nationals |
(-165) |
 Blue Jays vs  Rays |
(-105) |
 Orioles vs  White Sox |
(-140) |
 Yankees vs  Twins |
(-190) |
 Reds vs  Cardinals |
(-115) |
 Rangers vs  Astros |
(+105) |
 Giants vs  Diamondbacks |
(-130) |
 Phillies vs  Dodgers |
(-120) |
Odds updated from Caesars as of 9-15.
Expert MLB moneyline picks for September 15
Cubs vs Pirates: Pirates (+100)
Taking the Pittsburgh Pirates to win on Roberto Clemente Day would seem sentimental, and it isn't a good enough reason, as they're .500 on September 15 since donning the Clemente moniker, but SP Braxton Ashcraft has been rock solid, allowing just three earned runs over his last 21 2/3 innings, giving him the edge over Chicago Cubs SP Jameson Taillon.
Braves vs Nationals: Braves (-165)
Washington Nationals SP Mitchell Parker has the second-highest ERA among qualified starters at 5.69 (teammate Jake Irvin is slightly worse at 5.70). And for as shaky as Atlanta Braves righty Spencer Strider's been overall, he's boasted a 3.00 ERA over his last three outings (18 innings).
Blue Jays vs Rays: Rays (-105)
There will be some fanfare around Toronto Blue Jays starter Trey Yesavage, who is making his MLB debut against the Tampa Bay Rays tonight. However, for as well as he's pitched in the minors, his first taste of each level has been a bit sour. He walked four and allowed two runs in 1 2/3 innings in his first Triple-A start, while also walking four over four innings in his first foray into Double-A. Take the Rays, who always seem to have Toronto's number even at the best of times.
Orioles vs White Sox: Orioles (-140)
The Baltimore Orioles have looked better of late, and right-hander Kyle Bradish has pitched well since returning from injury (2.65 ERA and 21 strikeouts in 17 innings). He gets a soft landing against the Chicago White Sox today, and the offense should have a field day against Sean Burke.
Yankees vs Twins: Yankees (-190)
The Minnesota Twins are 3-7 across their last 10 and are officially out of the playoffs. Simeon Woods Richardson hasn't pitched beyond the fifth inning in any of his last nine starts and doesn't miss a ton of bats, which could mean an early look at a bullpen that saw its best arms sold off at the deadline. That's a recipe for disaster against Aaron Judge and the New York Yankees.
Reds vs Cardinals: Cardinals (-115)
This is almost a pick'em, but the St. Louis Cardinals should be favored by more. Even with Matthew Liberatore's second-half struggles, the Cincinnati Reds have the second-worst slugging percentage vs. left-handers this season, so I'll take the home team in the pitcher-friendly park.
Rangers vs Astros: Rangers (+105)
Texas Rangers right-hander Jack Leiter hasn't allowed more than three earned runs in any of his last 14 starts, boasting a 3.30 ERA in that stretch with 81 strikeouts in 71 innings. The Houston Astros are 4-6 in their last 10 and have fallen out of first in the AL West. Wyatt Langford and Jake Burger have been swinging hot bats and should make Jason Alexander's life miserable.
Giants vs Diamondbacks: Diamondbacks (-130)
Zac Gallen has never found his groove in 2025, but that shouldn't matter as the San Francisco Giants trot out Kai-Wei Teng and his 7.54 ERA. His peripherals have been better, but lefty bats have taken him to task (.318/.392/.364). The Arizona Diamondbacks just so happen to have one of the best in the game in Corbin Carroll, who has hit 23 of his 30 homers off righties.
Phillies vs Dodgers: Dodgers (-120)
This line is only as close as it is because Philadelphia Phillies SP Ranger Suarez is more of a known commodity than Los Angeles Dodgers RHP Emmett Sheehan, but the Phillies have clinched a playoff spot and have a 12-game lead in the NL East, while the Dodgers are still battling for the NL West crown. L.A. has one of the best home records in baseball (48-26), and Philly has barely been over .500 on the road.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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