MLB Home Run Predictions Today: Best HR Prop Bets, Picks, Parlay & Odds for Wednesday, May 6

Josh Inglis - Betting Analyst at Covers.com
Josh Inglis • Betting Analyst 13+ years betting experience
Updated: May 6, 2026 , 12:11 PM ET • 4 min read

Otto Lopez isn't your typical slugger, but the Marlins infielder has an insanely favorable matchup against Orioles SP Brandon Young and a great price point to target.

Otto Lopez Miami Marlins MLB
Photo By - Reuters Connect. Miami Marlins shortstop Otto Lopez (6) hits a single against the St. Louis Cardinals during the fifth inning at loanDepot Park.

The Okomoto Train got us on the board yesterday for a good one, and Wednesday's slate has a plethora of +EV home run picks and other great MLB player props.

After double-dipping with the Dodgers in the early afternoon, I'm grabbing Miami Marlins infielder Otto Lopez in a cushy matchup against Baltimore Orioles starter Brandon Young and the suspect bullpen behind him.

These are my favorite home run predictions for Wednesday, May 6.

  • UPDATE: Added another HR pick + parlay.

Best MLB home run props today

Player to hit a HR Odds
Dodgers Kyle Tucker  +542
Marlins Otto Lopez +800
Dodgers Shohei Ohtani +280
💲Today's HR parlay +14180
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Home run pick: Kyle Tucker (+542)

This one checks a lot of boxes, starting with the price. A fair number for a Kyle Tucker HR today is around +440/+450, so there’s plenty of meat on the bone.

Next is the matchup. Lance McCullers Jr. is one of the pitchers to fade today. His BlastContact% and HR/FB rates are among the worst in baseball, and he’s coming off a season-high 99 pitches. For a pitcher who has struggled to stay on the field, that kind of workload could show today.

Additionally, the Houston Astros' bullpen is always one to target and may need to cover innings. Houston relievers are also allowing the second-most HR/9 in baseball.

Finally, there’s a former-team revenge angle in an afternoon game, and Tucker has already taken him deep in just three at-bats.

  • Time: 2:10 p.m. ET
  • Where to watch: Space City Home Network, SportsNet LA

Home run pick: Otto Lopez (+800)

I need a piece of the bats vs. the Baltimore pitching today, and I'm landing at Otto Lopez at a giant +800 price. 

Brandon Young is my lowest-rated starting pitcher on the slate. He gives up squared-up contact at a high rate, and hitters generate some of their fastest swings against him. Only two other starters have a worse BlastContact% than the Baltimore arm, and his xFIP suggests the damage is sustainable.

Young also won’t go deep, handing things off to a bullpen that gives up home runs and owns the second-worst ERA in baseball over the last two weeks. The Baltimore pen could also be down three or four key arms.

It’s a controlled setting indoors, and Lopez is already 1-for-2 off Young with a home run.

  • Time: 6:40 p.m. ET
  • Where to watch: Marlins.TV, MASN

Home run pick: Shohei Ohtani (+280)

Let’s double up in Houston vs. McCullers and a struggling bullpen that will be without its closer, Bryan King, who threw 37 pitches yesterday.

Ohtani gets one of the best BlastContact% matchups on the board today and has seen McCullers 23 times. He hasn’t crushed him, but there’s still a lot of information he’s taking into this matchup.

The fair price on this HR is around +250, and it’s tough to pass up the expected value on arguably the best left-handed power hitter in baseball.

McCullers has allowed three home runs over his last 10 innings at home. Historically, he’s been tougher on left-handed hitters, but LHHs are getting the better of him this year, and multiple seasons of injury may be catching up to the right-hander.

  • Time: 2:10 p.m. ET
  • Where to watch: Space City Home Network, SportsNet LA
Josh Inglis' 2026 Transparency Record
  • HR picks: 10-59, -7.41 units

Today’s HR parlay

Dodgers Kyle Tucker Bet Now
+14180
Marlins Otto Lopez
Dodgers Shohei Ohtani

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Josh Inglis - Covers
Betting Analyst

Josh Inglis is a rising star in the sports betting content space, specializing in MLB, NHL, and NFL markets. Since joining Covers in 2019, Josh has focused his betting expertise on player props and derivative markets, finding them easier for beating the closing line compared to sides and totals. His engaging analysis and content have been showcased on major networks such as TSN, VSiN, BetMGM Network, and NBC. Josh is a prolific bettor, tracking over 2,500 bets annually and he consistently shares his results through monthly transparency reports. At Covers, he is renowned for his MLB release shows and NHL Puck Props, which are integral parts of the site's live content lineup.

Before his tenure at Covers, Josh spent a decade teaching while pursuing sports media on the side. He has also contributed to live global senior-level broadcasts for the WBSC.

Josh advocates for sports bettors to bet early, emphasizing the importance of securing better numbers by beating the public to the market. He also advises having multiple sportsbook accounts to ensure access to the best possible odds.

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