MLB Home Run Predictions Today: Best HR Prop Bets, Picks, Parlay & Odds for Sunday, September 21

Tony Sartori breaks down his favorite MLB home run predictions ahead of a packed MLB slate for Sunday, including Kyle Schwarber and Cal Raleigh.

Tony Sartori - Contributor at Covers.com
Tony Sartori • Betting Analyst
Sep 21, 2025 • 09:02 ET • 4 min read
Philadelphia Phillies outfielder Kyle Schwarber (12) bats against the Arizona Diamondbacks.
Photo By - Imagn Images. Philadelphia Phillies outfielder Kyle Schwarber (12) bats against the Arizona Diamondbacks.

There is a full 15-game MLB slate on Sunday, with plenty of MLB player props to choose from.

I have compiled my three best home run props for Sunday. As always, monitor the odds and available pricing, as the player prop market is constantly changing.

Here are my free MLB home run picks for Sunday, September 21.

Best MLB home run props today

  • TEAM Kyle Schwarber (+316)
  • TEAM Cal Raleigh (+250)
  • TEAM Jorge Polanco (+475)
  • 💲 +6938 parlay💲

Make your HR plays at DraftKings

Bet on your favorite home run props every day at DK, offering competitive odds and multi-HR props as well!

21+. Gambling problem? Call 1-800-GAMBLER.

HR Prop #1: Kyle Schwarber 

+316 at DraftKings

The Arizona Diamondbacks host the Philadelphia Phillies to kick off MLB’s afternoon slate. Left-hander Eduardo Rodriguez takes the mound for Arizona and should serve as a good fade candidate.

Through 27 starts this season, Rodriguez has posted a 5.12 ERA and 1.56 WHIP. His underlying metrics are equally poor, given that the southpaw ranks in the bottom third of the league in expected ERA (xERA) and expected batting average (xBA).

Philadelphia’s Kyle Schwarber is a strong candidate to take advantage of this matchup. He has homered in four of his past 11 games and boasts a .275 batting average, .625 slugging percentage, and 1.045 OPS during that stretch. He gets a spot in my MLB picks

HR Prop #2: Cal Raleigh

+250 at DraftKings

ESPN’s Sunday Night Baseball features the Houston Astros hosting the Seattle Mariners in a heated battle for divisional control.

Speaking of power hitters, there are few better right now than Seattle’s Cal Raleigh, who leads the league with 57 home runs. He has gone deep four times in his past six games, slashing .348/.913/1.357 over that span.

For the season, Raleigh ranks in the 96th percentile in expected slugging percentage (xSLG) and the 99th percentile in barrel rate.

HR Prop #3: Jorge Polanco

+475 at DraftKings

Another Mariners hitter to consider Sunday is Jorge Polanco. Right-hander Jason Alexander takes the mound for Houston, and he has had a year to forget.

Through 16 appearances, Alexander ranks in the bottom third of the league in xERA, xBA, strikeout rate, and hard-hit rate.

Polanco is a solid candidate to capitalize on those struggles, especially given his small but successful history against Alexander. He’s 1-for-2 in his career, and that one hit was a home run.

Today’s HR parlay

Kyle Schwarber

Cal Raleigh

Jorge Polanco

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.

Pages related to this topic

Tony Sartori - Covers.com
Betting Analyst

Tony Sartori has written over 1,000 pieces of sports betting content across multiple different media outlets. He covers the NHL, UFC, PGA, NFL and MLB. Tony started part-time while attending the University of Wisconsin-Madison, where he went on to receive a B.A. in Economics and a certificate in Entrepreneurship in 2022. He continues to work full-time in the sports betting landscape.

Due to the variety of sports he covers, Tony is handicapping every day. If he had one piece of betting advice for a new sports bettor, it would be to strictly enforce bankroll management rules for yourself. If you set aside $10,000 for your betting bankroll, then you should generally only be betting between $100 - $500 per play.

Popular Content

Covers is verified safe by: Evalon Logo GPWA Logo GDPR Logo GeoTrust Logo Evalon Logo