The Cleveland Guardians and Chicago White Sox wrap up a three-game set this afternoon at Rate Field, with the hosts looking for the sweep.
With Tanner Bibee struggling to avoid hard contact, my Guardians vs. White Sox predictions are leaning toward Chicago to bring out the brooms.
Read more in my MLB picks for Wednesday, June 24.
Who will win Guardians vs White Sox today: White Sox moneyline (+102)
The Cleveland Guardians head into the finale in the midst of a three-game losing streak, and Tanner Bibee's recent form concerns.
The right-hander has a 4.81 FIP over his last two starts while allowing 2.19 HR/9. That's a recipe for disaster against the second-best power-hitting team in the majors.
On the other side, Chicago White Sox righty Erick Fedde is throwing the ball well. He's posted a 2.15 FIP across his previous two outings while limiting opponents to a 23.8% hard-hit rate.
Cleveland also has just a .196 xBA over their last seven games and a poor 34.2% hard-hit rate.
I'll play this pick up to -120.
COVERS INTEL: Bibee has allowed a 46.6% hard-hit rate during his last two appearances and a 14.3% barrel rate. 
Guardians vs White Sox Over/Under pick: Under 8.5 (-107)
This feels like a game where Chicago scores most of the runs while Cleveland continues to struggle offensively.
Fedde's recent form makes him a difficult matchup for a Guardians lineup averaging just 2.33 runs per game during its current losing streak.
Cleveland's bullpen has been solid lately, posting a 3.95 xERA over the last two weeks, which should help prevent Chicago from completely running away with the game.
The White Sox bullpen hasn't been as sharp, with a 4.63 FIP, but Fedde typically works into the fifth inning and can limit the amount of relief work required.
I can see a 5-2 or 6-2 type game here.
I'll play this pick up to -130.
- ML/RL bets: 31-24, +4.65 units
- Over/Under bets: 31-23, +3.60 units
Guardians vs White Sox weather
Conditions at Rate Field are expected to be fairly neutral this afternoon, with temperatures around 78°F and moderate winds. While the weather could provide a slight boost to offense, it shouldn't be a major factor in determining the outcome of this game.
Guardians vs White Sox odds
- Moneyline: Guardians -108 | White Sox +104
- Run line: Guardians -1.5 (+144) | White Sox +1.5 (-150)
- Over/Under: Over 8.5 (-100) | Under 8.5 (-104)
Guardians vs White Sox trend
The White Sox have hit the moneyline in 21 of their last 25 games at home (+19.10 Units / 71% ROI). Find more MLB betting trends for Guardians vs. White Sox.
How to watch Guardians vs White Sox and game info
| Location | Rate Field, Chicago, IL |
| Date | Wednesday, June 24, 2026 |
| First pitch | 2:10 p.m. ET |
| TV | CleGuardians.TV, CHSN |
| Guardians starting pitcher | Tanner Bibee (2-8, 4.03 ERA) |
| White Sox starting pitcher | Erick Fedde (2-6, 4.46 ERA) |
Guardians vs White Sox latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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