The Cleveland Guardians have won nine of their last 10 games as they attempt to chase down the Detroit Tigers in the AL Central.
My Guardians vs. Tigers predictions expect a low-scoring affair to open up the three-game set.
Guardians vs Tigers prediction
Guardians vs Tigers best bet: Under 8 (-105)
We have a pitchers’ duel on tap tonight, with Casey Mize (14-5, 3.83 ERA) set to face off against Joey Cantillo (5-3, 3.36 ERA).
Mize has been especially strong at home this season, allowing 24 ER in 62 1/3 IP (3.47 ERA) as opposed to 32 ER in 69 1/3 IP (4.15 ERA) on the road.
The Cleveland Guardians have also been playing several low-scoring games in September. They’ve scored more than four runs in just one of their last nine games, and allowed more than two runs in just one of those nine as well.
The Detroit Tigers' bats have gone cold, too, with four runs or fewer in four straight games after two blowout wins at Yankee Stadium.
Guardians vs Tigers same-game parlay (SGP)
The Tigers are an impressive 46-29 at home this season, while the Guardians are 37-37 on the road. Furthermore, Detroit has won 10 of Mize’s 12 starts at home, including five straight.
Mize has 5+ strikeouts in 12 of 25 starts this season, including a six-strikeout game against the Guardians back in May.
Guardians vs Tigers SGP
- Under 8
- Tigers moneyline
- Casey Mize Over 4.5 strikeouts
Guardians vs Tigers odds
- Moneyline: Cleveland +120 | Detroit -140
- Run line: Cleveland +1.5 (-170) | Detroit -1.5 (+153)
- Over/Under: Over 8 | Under 8
Guardians vs Tigers trend
The Guardians have cashed the Under in 34 of their last 53 road games for +14.4 units and a 25% ROI. Find more MLB betting trends for Guardians vs. Tigers.
How to watch Guardians vs Tigers and game info
| Location | Comerica Park, Detroit, MI |
| Date | Tuesday, September 16, 2025 |
| First pitch | 6:40 p.m. ET |
| TV | CLEG, FDSN-Detroit |
| Guardians starting pitcher | Joey Cantillo (5-3, 3.36 ERA) |
| Tigers starting pitcher | Casey Mize (14-5, 3.83 ERA) |
Guardians vs Tigers latest injuries
Guardians vs Tigers weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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