Reigning division champs collide again at T-Mobile Park as the Cleveland Guardians and Seattle Mariners lock horns — and it’ll take some special hitting to top last night’s home run blitz.
These teams combined for six dingers in yesterday’s season opener, with Cleveland picking up a 6-4 win, and my Guardians vs. Mariners predictions expect Jose Ramirez to lead the charge for the visitors in this rematch.
Get the lowdown on this clash with my free MLB picks for Friday, March 27.
Guardians vs Mariners predictions
Guardians vs Mariners best bet: Jose Ramirez Over 1.5 total bases (+140)
If you’re in the market for consistent production, look no further than Jose Ramirez. His hit totals for the past four seasons read: 168, 172, 173, 168 – and there’s no sign of decline for the wily veteran.
Ramirez thumped a two-RBI double last night to turn the contest in the Cleveland Guardians favor, and he’s had success against Seattle Mariners starter George Kirby to the tune of a 6-for-12 record, with three doubles and a homer.
When the Mariners go to the bullpen, it’s worth noting that Ramirez also has a pair of hits against key relievers Gabe Speier and Andres Muñoz.
COVERS INTEL: George Kirby allowed a .264 average to left-handers last season, and that lines up nicely for the switch-hitting Ramirez and the other lefties in the Guardians lineup
Guardians vs Mariners same-game parlay (SGP)
I’ll take the run line with a pesky Cleveland offense that’s packed with lefties, while trusting that Gavin Williams – coming off a 3.06 ERA last year – can match Kirby.
The visitors, and they’ve got a real lead-off weapon in rookie Chase DeLauter, who marked his first regular season outing with two solo dingers last night.
Then it’s all about the elite hitting on show. Ramirez has already opened his RBI account for 2026, and Julio Rodriguez can point to three career hits against Williams. J-Rod went 0-for-4 yesterday, but he finished with 174 hits and 95 RBIs in 2025.
Guardians vs Mariners SGP
- Guardians +1.5
- Jose Ramirez Over 0.5 hits
- Julio Rodriguez Over 0.5 hits
Guardians vs Mariners home run pick: Cal Raleigh (+290)
After a magical run last year, Cal Raleigh didn’t do himself any favors during the WBC, but look for his bat to do the talking tonight. Another regular season with 60 homers might be a stretch, but I’m wagering on The Big Dumper to mash his first long ball of the year here.
- Best bets: 1-0, +0.65 units
- SGPs: 0-1, -1 units
- HR picks: 0-1, -1 units
Guardians vs Mariners odds
- Moneyline: Cleveland +143 | Seattle -158
- Run line: Cleveland +1.5 (-150) | Seattle -1.5 (+130)
- Over/Under: Over 7 (-105) | Under 7 (-115)
Guardians vs Mariners trend
The Over is 7-3 in the past 10 meetings between these teams. Find more MLB betting trends for Guardians vs. Mariners.
How to watch Guardians vs Mariners and game info
| Location | T-Mobile Park, Seattle, WA |
| Date | Friday, March 27, 2026 |
| First pitch | 9:45 p.m. ET |
| TV | Apple TV |
| Guardians starting pitcher | Gavin Williams (2025: 12-5, 3.06 ERA) |
| Mariners starting pitcher | George Kirby (2025: 10-8, 4.21 ERA) |
Guardians vs Mariners latest injuries
Guardians vs Mariners weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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