The Chicago Cubs took the series opener against the Cleveland Guardians, and the two clubs return to Wrigley Field for a rematch tonight.
My Guardians vs. Cubs predictions focus on Cleveland right-hander Tanner Bibee, who's in for a rough outing against this deep Chicago lineup.
Read more in my MLB picks for Wednesday, July 2.
Guardians vs Cubs prediction
My Guardians vs Cubs best bet: Tanner Bibee Under 17.5 outs recorded (+115 at DraftKings)
Cleveland Guardians righty Tanner Bibee has been handling a huge workload and has topped triple-digit pitches in three of his past five starts.
Bibbee's numbers are down across the board from his first two years in the league, and he’ll face a daunting Chicago Cubs lineup tonight.
The Cubs rank third in wOBA and fourth in ISO against right-handed pitchers, and Bibee has also struggled on the road with a 4.96 ERA and 1.31 WHIP.
Chicago even has a splash of statistical correction coming, with the second-lowest BABIP (.265) while averaging just 4.5 runs per game over the past 30 days. The Cubs have also posted a .299 BABIP, plating 5.78 runs per game across their first 59 of the season.
Guardians vs Cubs same-game parlay (SGP)
Tanner Bibee Under 17.5 outs recorded
Cubs -1.5
Jose Ramirez Over 1.5 hits + runs + RBI
The Guardians have been abysmal against southpaws this season with a 29th-ranked wOBA and 28th-ranked ISO, and Cubbies lefty Shota Imanaga showed off in his return to the mound with five scoreless innings in winning fashion last week.
I expect Imanaga to keep it rolling given his impressive 2.83 ERA and 1.02 WHIP across 38 career starts.
Turning to the final leg of this same-game parlay, Cleveland star Jose Ramirez terrorizes lefties and sports a high-end .373 wOBA, .251 ISO, and .907 OPS over the past three years.
Ramirez also hits in the heart of the lineup and is ripe for a breakout game given his active 3-for-27 stretch at the dish over the past seven games.
Guardians vs Cubs odds
Guardians vs Cubs live odds
Guardians vs Cubs opening odds
- Moneyline: Cleveland +140 | Chicago -155
- Run line: Cleveland +1.5 | Chicago -1.5
- Over/Under: Over 7.5 | Under 7.5
Guardians vs Cubs trend
Chicago has hit the moneyline in 41 of its last 70 games (+7.10 Units / 7% ROI). Find more MLB betting trends for Guardians vs. Cubs.
How to watch Guardians vs Cubs and game info
| Location | Wrigley Field, Chicago, IL |
| Date | Wednesday, 7-2-2025 |
| First pitch | 8:05 p.m. ET |
| TV | ESPN |
| Guardians starting pitcher | Tanner Bibee (4-8, 3.90 ERA) |
| Cubs starting pitcher | Shota Imanaga (4-2, 2.54 ERA) |
Guardians vs Cubs latest injuries
Guardians vs Cubs weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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