The Houston Astros host the Cleveland Guardians on Saturday, looking to wrap up their third straight series win, while the Guardians face the possibility of a fourth series loss in the last five.
Cleveland has lost seven of the last 10, and now first baseman Kyle Manzardo is battling back problems.
That's why my Guardians vs. Astros predictions and MLB picks are looking at a Houston win.
Who will win Guardians vs Astros today: Astros -1.5 (+152)
The odds make it tough to love the Houston Astros, as the moneyline is currently too steep.
If it drops to -120, it's worth taking the runs back. However, Houston has won nine games in June by a total of 31 runs—more than three runs per win.
The Cleveland Guardians have lost nine June games, also by 31. So there's good reason to believe a Houston win will cover the run line.
Cleveland starter Joey Cantillo has allowed batters a .343 average, 1.032 OPS, and production 74% over league average in his last four starts, posting a 9.00 ERA and WHIP over 2.00.
COVERS INTEL: Cantillo's underlying metrics are worse than his standard line. His fastball is in the bottom 2% in MLB for effectiveness and the bottom 13% for velocity. He's in the bottom third in baseball in walk rate, chase rate, barrel rate, and overall pitching run value.
Guardians vs Astros Over/Under pick: Over 8.5 (-103)
Houston's offense is getting hot. Yordan Alvarez leads the league in batting, slugging, OPS, OPS+, and homers. Jose Altuve looks like he's rounding into form in his third week since returning from injury.
He homered and drove in four in Friday's series opener.
Houston starter Spencer Arrighetti was the pitcher of the month for May but has yet to win in June, posting a 6.19 ERA and .286 average against in three starts this month.
Houston's bullpen has pitched 19 innings in the last three games. Cleveland's is more rested but has a 4.76 ERA and 2.29 WHIP over the last three.
- ML/RL bets: 22-27 -2.91 units
- Over/Under bets: 28-25, +2.04 units
Guardians vs Astros weather
Notes on the weather and its impact.
Guardians vs Astros odds
- Moneyline: Guardians +133 | Astros -138
- Run line: Guardians +1.5 (-163) | Astros -1.5 (+156)
- Over/Under: Over 8.5 (-100) | Under 8.5 (-108)
Guardians vs Astros trend
The Houston Astros have covered the Run Line in 16 of their last 25 games (+6.00 Units / 17% ROI). Find more MLB betting trends for Guardians vs. Astros.
How to watch Guardians vs Astros and game info
| Location | Daikin Park, Houston, TX |
| Date | Saturday, June 20, 2026 |
| First pitch | 7:15 p.m. ET |
| TV | FOX |
| Guardians starting pitcher | Joey Cantillo (5-3, 4.38 ERA) |
| Astros starting pitcher | Spencer Arrighetti (7-2, 2.57 ERA) |
Guardians vs Astros latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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