Cardinals vs Pirates Prediction, Picks & Odds for Today’s MLB Game

Our Cardinals vs. Pirates predictions expect Paul Skenes' relative struggles to continue against St. Louis.

Quinn Allen - Betting Analyst at Covers.com
Quinn Allen • Betting Analyst
Jul 1, 2025 • 09:08 ET • 4 min read
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This article contains predictions for an old game!

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Paul Skenes Pittsburgh Pirates MLB
Photo By - Imagn Images. Paul Skenes during a recent start against the Brewers.

The St. Louis Cardinals and Pittsburgh Pirates clash tonight in NL Central action at PNC Park. 

While Paul Skenes has been dominant this season, he’s giving up runs lately, and my Cardinals vs. Pirates predictions see value in the Over given his low total this evening. Read more in my MLB picks for Tuesday, July 1.

Cardinals vs Pirates prediction

My Cardinals vs Pirates best bet: Paul Skenes Over 1.5 earned runs (-120 at DraftKings)

Cardinals vs Pirates same-game parlay (SGP)

Paul Skenes Over 1.5 earned runs

Nolan Arenado 1+ hits

Bryan Reynolds 1+ hits

Cardinals vs Pirates odds

Cardinals vs Pirates live odds

Cardinals vs Pirates opening odds

  • Moneyline: St. Louis +140 | Pittsburgh -165
  • Run line: St. Louis +1.5 (-155) | Pittsburgh -1.5 (+130)
  • Over/Under: Over 7 | Under 7

Cardinals vs Pirates trend

The Pirates have cashed the run line in 21 of their last 32 games (+11.00 units / 27% ROI).. Find more MLB betting trends for Cardinals vs. Pirates.

How to watch Cardinals vs Pirates and game info

Location PNC Park, Pittsburgh, PA
Date Tuesday, 7-1-2025
First pitch 6:40 p.m. ET
TV FDSNMW, SNP
Cardinals starting pitcher Andre Pallante
(5-4, 4.43 ERA)
Pirates starting pitcher Paul Skenes
(4-7, 2.12 ERA)

Cardinals vs Pirates latest injuries

Cardinals vs Pirates weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Quinn Allen - Covers
Betting Analyst

Quinn Allen is an experienced sports journalist from Vancouver, Canada who fell in love with sports by the time he could walk. He proceeded to play high-level baseball and soccer growing up and eventually played college baseball in the United States.

After his career ended, Quinn received his broadcast journalism degree from BCIT and has since written for many sports publications including ClutchPoints, Gino Hard, and RG, where he plies his trade as a writer and editor.

Quinn's favorite team is Chelsea FC and he'd like to watch a match at Stamford Bridge one day. He loves to bet on NBA player props and encourages others to bet responsibly and not chase losses.

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