The Milwaukee Brewers host the St. Louis Cardinals in the final matchup of this three-game series at American Family Field.
My Cardinals vs. Brewers predictions focus on the total in this NL Central matchup.
Read on for my MLB picks for Sunday, September 14.
Cardinals vs Brewers prediction
Cardinals vs Brewers best bet: Over 8.5 (-120)
Right hander Miles Mikolas takes the mound for the St. Louis Cardinals and should serve as a good fade candidate. Through 28 starts this season, Mikolas is 7-10 with a 4.84 ERA and 1.32 WHIP.
His underlying metrics are even worse. Entering this matchup, Mikolas owns a 5.34 expected ERA (xERA) and .285 expected batting average (xBA). He also ranks in the third percentile in strikeout rate and fourth percentile in barrel rate.
These woes are likely to continue against the Milwaukee Brewers. Over the past six meetings, Mikolas is 2-3 with a 4.15 ERA and 1.30 WHIP against the Brewers.
On the other side, Milwaukee ranks in the Top 10 in runs scored per game, hits per game, on-base percentage (OBP), and OPS.
Meanwhile, the Brewers hand the ball to lefty Jose Quintana. Despite some solid surface-level results this year, Quintana ranks in the bottom third of the league in xERA, xBA, barrel rate, and hard-hit rate.
That expected regression could occur against St. Louis. Over his past nine meetings with the Cardinals, Quintana has posted a 5.40 ERA and 1.59 WHIP.
Cardinals vs Brewers same-game parlay (SGP)
Quintana has particularly struggled in the strikeout department. This season, he ranks in the eighth percentile in strikeout rate, sixth percentile in whiff rate, and 31st percentile in chase rate.
Meanwhile, Mikolas has recorded two or fewer strikeouts in four of his past five starts.
Cardinals vs Brewers SGP
- Over 8.5
- Jose Quintana Under 4.5 strikeouts
- Miles Mikolas Under 2.5 strikeouts
Cardinals vs Brewers odds
- Moneyline: St. Louis +150 | Milwaukee -178
- Run line: St. Louis +1.5 (-135) | Milwaukee -1.5 (+115)
- Over/Under: Over 8.5 (-120) | Under 8.5 (+100)
Cardinals vs Brewers trend
There have been 10 or more runs scored in three of the past four meetings between these two teams. Find more MLB betting trends for Cardinals vs. Brewers.
How to watch Cardinals vs Brewers and game info
| Location | American Family Field, Milwaukee, WI |
| Date | Sunday, September 14, 2025 |
| First pitch | 2:10 p.m. ET |
| TV | FDSN |
| Cardinals starting pitcher | Miles Mikolas (7-10, 4.84 ERA) |
| Brewers starting pitcher | Jose Quintana (11-6, 3.88 ERA) |
Cardinals vs Brewers latest injuries
Cardinals vs Brewers weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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