The Cincinnati Reds host the Milwaukee Brewers in the second matchup of this three-game series at Great American Ball Park. MLB odds list Milwaukee as a -130 favorite, while the total sits at nine.
My Brewers vs. Reds prediction targets a side in this NL Central matchup.
Read on for my MLB picks for Saturday, August 16.
Brewers vs Reds prediction
Brewers vs Reds best bet: Brewers moneyline (-130)
The Milwaukee Brewers look to break their club record and win their 14th consecutive game Saturday. The Brewers could do just that with right-hander Quinn Priester slated to take the mound.
Through 22 appearances this season, Priester is 11-2 with a 3.49 ERA and 1.24 WHIP. His underlying metrics are equally impressive, as he ranks in the top half of the league in expected ERA (xERA), walk rate and barrel rate.
This success is likely to continue against the Cincinnati Reds, a team he dominated the last time they met. In that outing, Priester allowed one run on two hits across two innings of work.
Milwaukee won that game 9-1.
Meanwhile, the Reds hand the ball to right-hander Zack Littell. Entering this matchup, Littell ranks in the bottom quarter of the league in xERA, expected batting average (xBA), average exit velocity and barrel rate.
Not only do the Brewers hold the pitching advantage, but they also possess the hitting edge. This season, Milwaukee outranks Cincinnati in runs per game, hits per game, slugging percentage and OPS.
Brewers vs Reds same-game parlay (SGP)
Brewers moneyline
Christian Yelich to record a hit
Andrew Vaughn to hit a home run
Milwaukee’s offensive production needs to continue against Littell to secure the win. Christian Yelich boasts a .333 batting average against him and has recorded 11 hits over the past four games.
Meanwhile, Andrew Vaughn has also been hot at the plate, homering in two of the past three games.
Brewers vs Reds odds
- Moneyline: Milwaukee -130 | Cincinnati +110
- Run line: Milwaukee -1.5 (+122) | Cincinnati +1.5 (-145)
- Over/Under: Over 9 (-123) | Under 9 (+101)
Brewers vs Reds trend
Milwaukee has won each of its past 13 games. Find more MLB betting trends for Brewers vs. Reds.
How to watch Brewers vs Reds and game info
| Location | Great American Ball Park, Cincinnati, OH |
| Date | Saturday, August 16 2025 |
| First pitch | 6:40 p.m. ET |
| TV | FDSNWI, FDSNOH |
| Brewers starting pitcher | Quinn Priester (11-2, 3.49 ERA) |
| Reds starting pitcher | Zack Littell (9-8, 3.60 ERA) |
Brewers vs Reds latest injuries
Brewers vs Reds weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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