We've got a good old-fashioned pitcher's duel set for Petco Park when Dylan Cease and the San Diego Padres host Chad Patrick and the NL Central-leading Milwaukee Brewers.
My Brewers vs Padres predictions are buying into pitching matchup and are targeting the game total Under.
My MLB picks for Wednesday, September 24, dive deeper into the 4:10 p.m. ET matchup.
Brewers vs Padres prediction
Brewers vs Padres best bet: Under 7.5 (-102)
The San Diego Padres have struggled at the plate this season. Entering this matchup, they rank in the Bottom half of the league in runs scored per game, slugging percentage, OPS, and home runs.
Those woes are likely to continue against righty Chad Patrick, who takes the mound for the Milwaukee Brewers. Through 25 appearances this year, Patrick has posted a 3.66 ERA and 1.28 WHIP.
Meanwhile, San Diego counters with RHP Dylan Cease. His analytics are impressive, as Cease ranks in the 72nd percentile or higher in xERA, expected batting average (xBA), strikeout rate, and hard-hit rate.
Cease has also proven capable of handling Milwaukee’s strong lineup. Through three career meetings, he owns a 3.57 ERA, 1.25 WHIP, and 12.23 strikeouts per nine innings (K/9).
Finally, both bullpens are more than capable of closing out this game. This season, both teams’ relief corps rank in the Top 5 in fielding independent pitching (FIP) and wins above replacement (WAR).
Brewers vs Padres same-game parlay (SGP)
William Contreras has struggled against Cease, going 1-for-9 with four strikeouts. Over that stretch, Contreras owns a .096 expected batting average (xBA) and a .090 expected weighted on-base average (xwOBA). Don't expect him to do any damage today.
Brewers vs Padres SGP
- Under 7.5
- Padres moneyline
- William Contreras Under 0.5 total bases
Brewers vs Padres odds
- Moneyline: Milwaukee +110 | San Diego -135
- Run line: Milwaukee +1.5 (-200) | San Diego -1.5 (+165)
- Over/Under: Over 7.5 (-120) | Under 7.5 (-102)
Brewers vs Padres trend
There have been seven or fewer total runs scored in four of Patrick’s past six starts. Find more MLB betting trends for Brewers vs. Padres.
How to watch Brewers vs Padres and game info
| Location | PETCO Park, San Diego, CA |
| Date | Wednesday, September 24, 2025 |
| First pitch | 4:10 p.m. ET |
| TV | FDSNWI, SDPA, MLBN |
| Brewers starting pitcher | Chad Patrick (3-8, 3.66 ERA) |
| Padres starting pitcher | Dylan Cease (8-12, 4.64 ERA) |
Brewers vs Padres latest injuries
Brewers vs Padres weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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