It's Dylan Cease bump day, so you know we have to ride with the ace in our Blue Jays vs. Guardians prediction.
The Toronto Blue Jays are -130 betting favorites at BET99, and our best play of the day centers around the Cy Young Award candidate. Can he limit the Cleveland Guardians' bats and tie the series?
Let’s dive into my MLB picks for Wednesday, Sept. 2.
Blue Jays vs Guardians predictions
Blue Jays vs Guardians best bet: Dylan Cease Under 4.5 Hits (-120)
Dylan Cease has coughed up more than four hits just once in over a month and is in a prime position to limit the Cleveland Guardians' bats tonight.
Across 114 plate appearances, the Guardians own just a .388 xSLG against him — hard contact from this lineup comes rarely when the Cy Young odds candidate is on the bump, which puts us in a good spot to fly Under the number.
With a hard-hit rate (32.3%) in the 88th percentile among qualified pitchers, don't expect much good contact from Cleveland's bats tonight.
I'd play this up to -130.
Looking for expert plays for the entire slate? Our team has you covered with our MLB expert picks for Sept. 2.
COVERS INTEL: Cease's opponents own a .185 xBA or worse against his four-seamer, slider, and changeup, the three pitches he throws the most. 
Blue Jays vs Guardians same-game parlay (SGP)
I don't put this lightly: in the broader scope of the Wild-Card race, this is a must-win game for the Blue Jays. They have their ace on the mound, they dropped Game 1, and are now 2.5 games back of the final spot, which currently belongs to Cleveland.
Elsewhere, Alejandro Kirk has been one of baseball's hottest hitters, owning a .898 OPS since the All-Star break. Let's win our third SGP in four days, shall we?
Blue Jays vs Guardians SGP
- Dylan Cease Under 4.5 hits
- Toronto Blue Jays moneyline
- Alejandro Kirk 2+ hits + runs + RBI
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Regulated Alberta sports betting has officially launched, allowing sportsbooks to operate under provincial oversight.
You can sign up and join BET99 — one of the best Alberta betting apps — now to get in on the Blue Jays action!
Blue Jays vs Guardians home run pick: Kazuma Okamoto (+380)
Kazuma Okamoto is always a good bet to go yard on any given night. He's already registered a dinger against Joey Cantillo, and owns a .860 OPS against lefties this season. I'll fire him up against a pitcher rocking a 38.8% hard-hit rate.
- Best bets: 9-10, +1.53 units
- SGPs: 4-15, -0.26 units
Blue Jays vs Guardians odds
- Moneyline: Toronto (-130) | Cleveland (+110)
- Run line: Toronto -1.5 (+135)| Cleveland +1.5 (-160)
- Over/Under: Over 7 (-120) | Under 7 (+100)
Blue Jays vs Guardians trend
The Blue Jays are 9-0 in their last nine games after scoring two runs or less in their previous game. Find more MLB betting trends for Blue Jays vs. Guardians.
How to watch Blue Jays vs Guardians and game info
| Location | Progressive Field, Cleveland, Ohio |
| Date | Wednesday, Sept. 2, 2026 |
| First pitch | 6:40 p.m. ET |
| TV | CleGuardians.TV, SN |
| Blue Jays starting pitcher | Dylan Cease (9-5, 2.34 ERA) |
| Guardians starting pitcher | Joey Cantillo (9-7, 3.70 ERA) |
Blue Jays vs Guardians latest injuries
Blue Jays vs Guardians weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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