The Houston Astros will look to complete a season series sweep when they meet the Arizona Diamondbacks in hitter-friendly Chase Field tonight.
Jose Altuve has been on fire, and my Astros vs. Diamondbacks predictions don't expect his hot bat to cool down in the Arizona heat.
Read on for my MLB picks for Wednesday, July 23.
Astros vs Diamondbacks prediction
My Astros vs Diamondbacks best bet: Jose Altuve Over 1.5 total bases (+120 at bet365)
Jose Altuve enters today's matchup with two or more total bases in seven of his last 10 while batting .365 with a 1.123 OPS in July.
Arizona Diamondbacks SP Brandon Pfaadt has struggled against right-handed hitters this season, allowing a .258 average, seven home runs, and a .303 BABIP.
Altuve’s .288/.347/.476/.874 slash line with 14 home runs and 17 extra-base hits in 319 at-bats is solid, but his .303 BABIP against RHP hints towards a massive day.
If Altuve doesn’t crush Pfaadt, his .333/.380/.581/.961 slash line with five homers and eight extra-base hits in 93 career at-bats against this Arizona bullpen gives us hope that he can crush just about any hurler the D-Backs throw his way.
Astros vs Diamondbacks same-game parlay (SGP)
Jose Altuve 2+ total bases
Christian Walker 2+ total bases
Over 6.5
Christian Walker has two or more total bases in five of his previous 10, and 12 bombs with a dozen extra-base hits against righties. His .299 BABIP suggests another strong day at the dish.
Houston Astros starter Brandon Walter has allowed five bombs and 15 earned runs across 28 road innings. He meets an Arizona offense that’s scored only four runs in this series but averages 5.23 runs per game at home.
We’ve already documented Phaadt’s issues, and all these factors should lead to at least seven runs today, clearing the 6.5 alt run game total.
Astros vs Diamondbacks odds
Astros vs Diamondbacks live odds
Astros vs Diamondbacks opening odds
- Moneyline: Houston -102 | Arizona -116
- Run line: Houston -1.5 (+168) | Arizona +1.5 (-202)
- Over/Under: Over 8.5 | Under 8.5
Astros vs Diamondbacks trend
The Arizona Diamondbacks have hit the game total Over in 30 of their last 48 games (+11.35 Units / 21% ROI). Find more MLB betting trends for Astros vs. Diamondbacks.
How to watch Astros vs Diamondbacks and game info
| Location | Chase Field, Phoenix, AZ |
| Date | Wednesday, 7-23-2025 |
| First pitch | 3:40 p.m. ET |
| TV | SCHN, ARID |
| Astros starting pitcher | Brandon Walter (1-3, 3.66 ERA) |
| Diamondbacks starting pitcher | Brandon Pfaadt (3-6, 5.94 ERA) |
Astros vs Diamondbacks latest injuries
Astros vs Diamondbacks weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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