Duke Blue Devils vs Michigan State Spartans Prediction, Picks, Prop Bets For December 06, 2025

DUKE vs MSU Picks

Total

u142.5 (-110)

Best Odds

u141.5 -108

Pick made: 2 months ago

u141.5 -108

u141.5 -110

u141.0 -110

This will be the fourth matchup of these schools in the 2020s, with Duke winning two of three, with all games at Cameron Indoor. As the scene shifts to the Breslin Center for the first time since 2019, it’s a clear advantage for Michigan State, who are a whopping 116-16 under Tom Izzo at home in December. Still, it’s a little too close to call, so we’ll stick with the prevailing trend on the total and trust the defense: Duke has cashed the Under in six straight games, while MSU has gone Under in six of the last seven.

Rank	Leader	L10	Units
1	sportsdool1123	6-4-0	+7450
2	KushMartin2	10-0-0	+5500
3	chefsloan7	7-3-0	+5400
4	ziggy26	8-2-0	+5250
5	BammBamm64	8-2-0	+4850
6	BundiniBrown	6-4-0	+4800
7	kermitfrog	5-5-0	+4650
8	BillyJack	8-2-0	+4200
9	Geo Lazos	6-4-0	+4200
10	dmpp099	7-3-0	+4150
All Blue Devils Money Leaders

Rank	Leader	L10	Units
1	chuluckus	5-5-0	+8850
2	Sandsaver727	4-6-0	+7250
3	AlmightyDragon	7-3-0	+6400
4	Ollywood	4-6-0	+6200
5	PSUman19	8-2-0	+4750
6	DavePaliwoda	5-5-0	+4700
7	lenny2098	4-6-0	+4600
8	burley	4-6-0	+4550
9	vikings53098	9-1-0	+4400
10	pskerry	7-3-0	+4250
All Spartans Money Leaders

Duke @ Michigan State Picks & Props

DUKE vs MSU Picks

DUKE vs MSU Consensus Picks

48% picking Duke

66% picking Duke vs Michigan St. to go Over

DUKE vs MSU Trends

Duke has hit the Moneyline in 37 of their last 39 games (+31.95 Units / 1% ROI)

Duke have covered the Spread in 26 of their last 40 games (+10.60 Units / 24% ROI)

Duke has hit the 1H Moneyline in 12 of their last 13 away games (+9.25 Units / 2% ROI)

Duke has hit the 1H Game Total Over in 11 of their last 13 away games (+8.75 Units / 59% ROI)

Duke have covered the 1H Spread in 25 of their last 40 games (+7.65 Units / 17% ROI)

Duke has only hit the 1H Game Total Under in 2 of their last 13 away games (-10.65 Units / -71% ROI)

Duke has only hit the Team Total Under in 4 of their last 13 away games (-6.25 Units / -42% ROI)

Michigan State has hit the Moneyline in 31 of their last 36 games (+22.10 Units / 2% ROI)

Michigan State has hit the Game Total Under in 27 of their last 36 games (+17.10 Units / 43% ROI)

Michigan State have covered the Spread in 26 of their last 36 games (+15.00 Units / 38% ROI)

Michigan State has hit the 1H Game Total Under in 23 of their last 36 games (+8.30 Units / 20% ROI)

Michigan State has hit the Team Total Under in 12 of their last 22 games at home (+1.79 Units / 7% ROI)

Michigan State has only hit the Game Total Over in 9 of their last 36 games (-20.80 Units / -52% ROI)

Michigan State has only hit the 1H Game Total Over in 13 of their last 36 games (-13.80 Units / -33% ROI)

Michigan State have only covered the 1H Spread in 16 of their last 36 games (-6.95 Units / -17% ROI)

Michigan State has only hit the Team Total Over in 9 of their last 22 games at home (-4.95 Units / -19% ROI)

Michigan State has only hit the 1H Moneyline in 21 of their last 36 games (-3.10 Units / -0% ROI)

DUKE vs MSU Top User Picks

Duke Team Leaders

Michigan St. Team Leaders

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