Chicago @ San Diego picks

Manny Machado is off to a hot start for the San Diego Padres. After finishing with an OPS below .800 in back-to-back seasons, the 32-year-old is in vintage form with a .317/.379/.483 slash line (.862 OPS) through 60 plate appearances. He performed very well at Petco Park a year ago with a 132 wRC+ (112 on the road), .282 BA (.268), and .811 OPS (.785). So far in 2025, those home-road splits have continued (159 wRC+ at home, 138 wRC+ on the road). Chicago Cubs hurler Jameson Taillon takes the mound with a 6.06 ERA through three starts. The veteran ranks in the 20th percentile in xBA and the 24th percentile in xERA, so it looks unlikely that he will repeat his 3.27 ERA of a season ago.