Jaguars vs Saints Prediction, Picks & Odds for This Week’s NFL Preseason Game

The Saints' Swiss cheese defense will be exploited all game long by the Jaguars, as our NFL betting picks explain.

Jason Ence - Contributor at Covers.com
Jason Ence • Betting Analyst
Aug 16, 2025 • 18:05 ET • 4 min read

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Jacksonville Jaguars NFL Cam Little
Photo By - Imagn Images. Jacksonville Jaguars place kicker Cam Little (39) points skyward after a field goal.

The Jacksonville Jaguars and New Orleans Saints will meet on Sunday in NFL preseason action from the Caesars Superdome as both teams look to pick up their first exhibition win.

The Jaguars likely won’t have Travis Hunter, but Trevor Lawrence should see a couple of series. The Saints hope to see some separation in their quarterback battle, with rookie Tyler Shough confirmed as the starter.

Read on for my Jaguars vs. Saints predictions and NFL picks for Sunday, August 17, as I tell you why Jacksonville will score early and often. 

Jaguars vs Saints prediction

Jaguars vs Saints Best bet: Jaguars to score in every quarter (+240 at bet365)

While the Jacksonville Jaguars lost 31-25 to the Steelers in their preseason opener, the offense performed well. Their starters played just one series, and had a solid drive going, but a costly penalty stalled it out before Cam Little drilled a 41-yard field goal.

It turns out that kick would be one of four that Little converted on the day. He later kicked an unbelievable 70-yard field goal to end the first half, and tacked on a 52-yard effort late in the game. 

Thanks to his four kicks, the Jaguars scored in each of the game’s quarters. And with how their quarterback play looked in the second half, I like them to do so yet again at a price that is more than fair.

The New Orleans Saints had one of the worst defenses in the NFL during the second half of the season, and they surrendered multiple big runs last week to the Chargers as they coughed up 27 points. Los Angeles scored in every quarter except the first, where they muffed a punt and got poor quarterback play from Taylor Heinicke.

Liam Coen indicated the Jaguars' starters will get more time this week, so scoring early points shouldn’t be an issue. And both Nick Mullens and Seth Henigan performed well against a Pittsburgh defense that is expected to be deeper than what New Orleans has to offer.

The Saints had the second-worst run defense in the NFL a season ago, and surrendered the sixth-most passing yards. If the Jaguars cross midfield, Little has shown he can put points on the board. That makes the odds of +240 worth the risk here. 

Jaguars vs Saints odds

  • Spread: Jaguars -2.5 | Saints +2.5
  • Moneyline: Jaguars -144 | Saints +118
  • Over/Under: Over 38.5 | Under 38.5

How to watch Jaguars vs Saints

Location: Caesars Superdome, New Orleans, LA
Date: Sunday, 8-17-2025
Kickoff: 1:00 p.m. ET
TV: NFL Network

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Jason Ence - Covers
Betting Analyst

Jason has been hooked on soccer since watching Real Madrid and Manchester United in the 2003 Champions League, and has been betting on the sport for nearly 15 years. He has given soccer gambling and fantasy advice for nearly a decade, writing for sites including Rotowire, SB Nation, and The TwinSpires Edge.

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