The Chargers and Raiders each seek a 2-0 start as they collide in the latter half of a Week 2 Monday Night Football doubleheader.
Don't miss our best bets in our Chargers vs. Raiders predictions and NFL picks for this showdown from Allegiant Stadium in Las Vegas on September 15.
Chargers vs Raiders predictions for Monday Night Football
- Raiders +3.5 (-110 at bet365)
- Over 46.5 (-110 at bet365)
- Allen TD (+225 at bet365)
- Jeanty o66.5 rush yds (+100 at bet365)
Chargers vs Raiders MNF best bets
Raiders +3.5
Rohit Ponnaiya liked what he saw from the Raiders in Week 1 and believes that momentum will roll into tonight.
"Given how well the Raiders played in their first game under Pete Carroll I have a slight lean towards them at anything above the key number of 3. Especially now that Bowers is expected to suit up."
Over 46.5
Ponnaiya believes Geno Smith will help get this game Over the total.
"Smith looked terrific in his Las Vegas Raiders debut last week, completing 24 of 34 passes for 362 yards. Chip Kelly's up-tempo offense looked like a natural fit for Smith, who had four completions 20+ yards downfield against the Patriots. He'll attack a Los Angeles Chargers defense that looks due for regression after outperforming expectations in 2024."
Chargers vs Raiders MNF TD picks
Keenan Allen
Eric Rosales is backing veteran WR Keenan Allen in the touchdown department tonight.
"It was quite the 2025 debut for Justin Herbert, as he shredded the Chiefs for 318 yards passing and three TDs. One of those went to old reliable Keenan Allen, who is back and has added another layer to the passing game between deep threat Quentin Johnson and underneath guy Ladd McConkey."
Chargers vs Raiders MNF props
Ashton Jeanty Over 66.5 rushing yards
Ed Scimia sees the Raiders calling Ashton Jeanty's number early and often in Week 2.
"Jeanty should have a bit of a softer matchup in Week 2. As good as the Chargers looked overall against the Chiefs, they did allow Kansas City to run for 5.8 yards per carry, a number that the Raiders will certainty look to exploit."
Chargers vs Raiders odds
Chargers vs Raiders game info
| Location: | Allegiant Stadium, Las Vegas, NV |
| Date: | Monday, September 15, 2025 |
| Kickoff: | 10:00 p.m. ET |
| TV: | ESPN |
Chargers vs Raiders latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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