Stanford vs BYU Prediction, Picks & Odds for September 6 — College Football Week 2

Yonke's prediction: Defenses dominate in late-night showdown.

JD Yonke - Betting Analyst at Covers.com
JD Yonke • Betting Analyst
Sep 6, 2025 • 06:00 ET • 4 min read

NCAAF

Match starts: 13 hrs
BYU
65 %
STAN
35 %
Read Analysis
Bodie Schoonover BYU Cougars NCAAF
Photo By - Imagn Images. BYU Cougars defensive end Bodie Schoonover (48).

The Stanford Cardinal head to Provo for a late kickoff with the BYU Cougars tonight.

Stanford got off to a slow start with a loss to Hawai’i in Week 0, whereas BYU demolished Portland State in Week 1.

My Stanford vs. BYU predictions expect the Under to come through. Find out more in my college football picks for Saturday, September 6.

Stanford vs BYU prediction

Stanford vs BYU best bet: Under 45.5 (-110)

There’s no other way to put it — the Stanford Cardinal offense was dreadful in the opener against Hawai’i, mustering 286 total yards on 3.9 yards per play.

Quarterback Ben Gulbranson completed 15 of his 30 attempts for 109 yards with an interception but no touchdowns. Per PFF, he was the lowest-graded starting quarterback this season with a 29.3 passing grade, three turnover-worthy passes, and zero big-time throws.

Expect the Cardinal to shell up, run the ball, and hope to gain some first downs and keep the clock moving. This attempt to shorten the game and protect their starting QB should lead to a low-scoring game as long as the defense holds up.

The BYU Cougars managed 69 points in the opener against Portland State, but keep in mind that came against a miserable FCS defense that surrendered 40.0 ppg a year ago. BYU’s defense was utterly dominant, allowing 51 total yards on 1.2 yards per play, which is arguably the biggest takeaway from the 69-0 cakewalk.

BYU should continue to improve defensively in Year 3 under respected coordinator Jay Hill, and the offense is unproven, led by true freshman pivot Bear Bachmeier.

Stanford vs BYU same-game parlay

It’s difficult to see Stanford contributing much in the scoring department, especially on the road at a raucous LaVell Edwards Stadium.

BYU won 11 games last season, highlighted by a blowout win (36-14) over Colorado in the Alamo Bowl. The big storyline this offseason was the turnover at the quarterback position, but the Cougars are still a dangerous program.

Stanford vs BYU same game parlay

  • BYU -20.5
  • Under 45.5
  • Under 23.5 — 1st Half

Our deep-ball SGP: Cougars pull away late

Stanford will attempt to muddy the game up and limit possessions, which could keep things tight and low-scoring to start.

BYU’s superior offense should pull away late, especially once star running back LJ Martin gets cooking.

Stanford vs BYU same game parlay

  • BYU -20.5
  • Under 45.5
  • Under 23.5 — 1st Half
  • BYU -4.5 — 3rd Quarter
  • BYU -4.5 — 4th Quarter

Stanford vs BYU odds

  • Spread: Stanford +18 (-110) | BYU -18 (-110)
  • Moneyline: Stanford +800 | BYU -1300
  • Over/Under: Over 47.5 (-110) | Under 47.5 (-110)

Stanford vs BYU trend to know

Stanford has hit the Under in eight of its last 12 games. Find more college football betting trends for Stanford vs BYU.

How to watch Stanford vs BYU

Location LaVell Edwards Stadium, Provo, UT
Date Saturday, September 6, 2025
Kickoff 10:15 p.m. ET
TV ESPN

Stanford vs BYU latest injuries

Stanford vs BYU weather

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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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JD Yonke
Betting Analyst

JD is a diehard college football fan with five years of experience writing betting and fantasy content for publications such as SportsGrid, Fantasy Points, Fantrax, and Devy Watch. An avid reader, he uses his inclination to look at things with an exhausting and in-depth, analytic viewpoint combined with a love for statistics and metrics to form a well-rounded handicapping approach.

e's an integral member of the niche (but growing!) college fantasy football community, twice traveling to Canton, OH for the Fantasy Football Expo as a member of the CFF King's Classic drafting squad. His specialization in college football DFS and prop betting taught him that there are exploitable markets to be found and that narrowing your focus is integral to being a profitable bettor.

A lifelong Californian who grew up playing baseball, basketball, football, and lacrosse, he's glad to share a passionate love for sports with this wonderful community.

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