While many of the top teams have massive spreads to overcome in Week 2, there are still some intriguing early-season matchups on the board.
That includes Michigan heading to Norman to take on Oklahoma in prime time and a rivalry affair between Iowa and Iowa State. I pick a side in my Week 2 moneyline college football picks below.
Week 2 college football moneyline picks
| Matchup | Pick |
|---|---|
 Iowa vs  Iowa State |
(-154) |
 Illinois vs  Duke |
(+130) |
 Virginia vs  NC State |
(+106) |
 Baylor vs  SMU |
(+108) |
 Mississippi vs  Kentucky |
(-365) |
 Kansas vs  Missouri |
(-230) |
 Michigan vs  Oklahoma |
(-184) |
 UCLA vs  UNLV |
(+118) |
Lines courtesy of FanDuel as of 9-3.
Expert Week 2 CFB moneyline picks
Iowa vs Iowa State: Iowa State (-154)
No. 16 Iowa State is off to a dream 2-0 start and gets to take on its biggest rival at home after beating a ranked Iowa team on the road a year ago. Iowa State wins a low-scoring game and moves to 3-0.
Illinois vs Duke: Duke (+130)
Aside from the generous No. 11 ranking Illinois has, there isn't much separating these squads at this point in the season. Darian Mensah was excellent in Week 1, and I think he leads the Blue Devils to a win as slight home dogs.
Virginia vs NC State: Virginia (+106)
NC State is a slight home favorite, but with Chandler Morris a full go following last week's shoulder injury, I'm leaning the way of Virginia.
Baylor vs SMU: Baylor (+108)
Despite a Week 1 loss to Auburn, I'm not out on Sawyer Robertson & Co. just yet. Give me the Bears to bounce back against a SMU squad due for regression following last year's CFP appearance.
Mississippi vs Kentucky: Mississippi (-365)
Kentucky threw for just 85 yards and was actually outgained 329-305 in its win over Toledo. Mississippi is a test the Wildcats simply aren't ready for.
Kansas vs Missouri: Missouri (-230)
Jalon Daniels is rolling to start the year and has the ability to keep this close, but I expect the Tigers to edge this out and move to 2-0.
Michigan vs Oklahoma: Oklahoma (-184)
Bryce Underwood looked awesome in his first start, but I expect a much different outcome as he hits the highway for his first true test.
UCLA vs UNLV: UNLV (+118)
UCLA's shaky offensive line will be its undoing once again. Give me the 2-0 Rebels at home.
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