LSU vs Clemson Same-Game Parlay for College Football Week 1

Our LSU vs. Clemson SGP picks believe Bryant Wesco will be the beneficiary of a big day from Cade Klubnik as Clemson rolls over LSU.

Andrew Caley - Senior Betting Analyst at Covers.com
Andrew Caley • Senior Betting Analyst
Aug 30, 2025 • 08:27 ET • 4 min read
Clemson Tigers Bryant Wesco Jr. NCAAF
Photo By - Imagn Images. Clemson Tigers wide receiver Bryant Wesco Jr. in NCAAF action.

It’s the battle of the Tigers. The two Death Valleys. And two Heisman hopeful quarterbacks. And while a lot of this game looks like a toss-up, my SGP for this Top 10 matchup clearly favors one QB over the other, and that's Cade Klubnik.

For a complete breakdown and more college football picks for this game, check out my LSU vs. Clemson predictions.

Our best LSU vs Clemson SGP for Week 1

The difference for me in this matchup is simple. Clemson Tigers QB Cade Klubnik will have more time to operate in the pocket and attack downfield compared to LSU Tigers QB Garrett Nussmeier.

Nussmeier is working behind an offensive line that has to replace several impact players, including first-round pick Will Campbell. And that inexperienced line must deal with a Clemson defensive line that has NFL talent in Peter Woods and TJ Parker.

Meanwhile, Klubnik will have the benefit of facing a suspect LSU defense. The Bayou Bengals ranked 75th in defensive success rate last season and now must replace all four starters on the defensive line. 

So, one way LSU may try to make up for that is by blitzing Klubnik, and his improved touch with his deep ball could burn the Bayou Bengals. Not only should Klubnik use his arm to lead Clemson to a cover but go Over 260.5 passing yards. It's something he did in six of his final nine games last season.

And one of the recipients of those deep balls should be Bryant Wesco. The super sophomore went for 708 yards and five scores as a true freshman he could take another leap in his development this season.

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Andrew Caley
Senior Betting Analyst

When his dreams of becoming the next Steve Nash died, all Andrew "Taco" Caley wanted to do was write about sports, something he's been doing at Covers for more than a decade. A Journalism School grad from Holland College in Charlottetown, PEI, Andrew previously worked at The Chronicle Herald and Star Metro, but knew in his heart that his future lay in sports. He began at Covers as a news editor and has now done everything under the sun when it comes to content. His work has been seen on TSN, Sportsnet, VSiN, and CBS. These days Andrew's betting expertise is focused on his favorite teams; the Toronto Blue Jays and Toronto Raptors. He's also an avid college football fan and bettor. He can't be friends with you if you don't appreciate a Service Academy Under. The sportsbook where he does the bulk of his betting is bet365 thanks to its numerous prop betting options and competitive odds. His best advice? Find the balance between the numbers and what you see on the playing field. Then find the best price using multiple books. And don’t ask him where the nickname Taco comes from. It's not an interesting story. Seriously.

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