The game of the night in college football is in Kentucky, where the Louisville Cardinals host the James Madison Dukes under the lights.
The Dukes have been a trendy Group of Five underdog since joining the FBS, but they may be overmatched against this talented and deep Louisville squad.
So, I’ve cooked up an SGP that has the Cardinals flying on Friday night, and for more college football picks for this matchup, check out my James Madison vs. Louisville predictions.
Our best James Madison vs Louisville SGP for Week 2
Since joining the FBS in 2023, the James Madison Dukes have gone 8-3, 11-2, and 9-4, and are once again one of the favorites to win the Sun Belt.
However, success for a Group of Five program in the NIL and transfer portal era can mean your roster gets pillaged by bigger programs. While QB Alonza Barnett returns, the Dukes must replace 12 starters.
Meaning they will be in tough here. This is arguably Jeff Brohm's best team since coming to Louisville.
It will be a productive night for the Cardinals all around. With former USC QB Miller Moss under center, this is a balanced offense, but running the football remains their bread and butter.
Isaac Brown is a stud. He rushed for 1,173 yards at 7.1 yards per carry and 11 scores last season, picking up right where he left off, going for 126 yards and two touchdowns on just six attempts in the season-opening win over EKU. I like him to top the century mark once again.
Moss did his part too, throwing for 223 yards in one half of action. He should play a little more in this one and top his passing yard prop of 250.5.
Moss and Brown will power the Cardinals to a win and cover on Friday night.
James Madison vs Louisville same-game parlay
- Louisville -13.5
- Isaac Brown Over 99.5 rushing yards
- Miller Moss Over 250.5 passing yards
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