The late timeslot for Week 9 features two key SEC matchups — Oklahoma vs. Tennessee and South Carolina vs. Mississippi — as well as a Big Ten showdown between USC and Nebraska, plus Cincinnati traveling to Rice-Eccles to face Utah in the Pac-12 after dark memorial game.
Our college football experts have a best bet for all of those games — and more — to wrap up the week, so read on to see our favorite college football picks and analysis!
College football best bets for Week 10 late games
| Game | Time (ET) Network |
Best bet |
|---|---|---|
 vs  |
7:00 | ESPN | Chambliss o267.5 pass -114 |
 vs  |
7:00 | BTN | -21.5 -122 |
 vs  |
7:30 | ABC | ML +122 |
 vs  |
7:30 | NBC | Miller o94.5 rush -114 |
 vs  |
7:30 | ESPN2 | Over 58.5 -105 |
 vs  |
7:30 | SECN | -10.5 -110 |
CFB Week 10 preview with Andrew Caley and Douglas Farmer
College Football Week 10 LIVE Preview with Douglas Farmer and @Covers_Caley https://t.co/nJY1E7k75l
— Douglas Farmer (@D_Farmer) October 30, 2025
South Carolina vs Mississippi best bet
Trinidad Chambliss Over 267.5 passing yards (-114 at FanDuel)
The Gamecocks were oh-so-close to upsetting Alabama last week. However, after that disappointment, the Gamecocks should come back down to Earth and are set up for a letdown. That doesn’t bode well against this explosive Rebels offense... nor does the fact that South Carolina ranks 117th in the country in defensive success rate on dropbacks.
See our full analysis and Gamecocks/Rebels SGP in our South Carolina vs. Mississippi predictions.
Purdue vs Michigan best bet
Purdue +21.5 (-122 at FanDuel)
Michigan is not going to throw the ball up and down the field, and they're not a team I'm looking to lay a lot of points with.
See our other early college football Week 10 picks from the Covers YouTube channel.
Oklahoma vs Tennessee best bet
Oklahoma moneyline (+122 at FanDuel)
The Volunteers are now back to being a one-sided SEC imposter. Tennessee’s offense can still produce — No. 12 in expected points added (EPA) per snap — but it falls into disarray against the best competition... and also: Tennessee cannot defend.
See our full analysis and Sooners/Volunteers SGP in our Oklahoma vs. Tennessee predictions.
USC vs Nebraska best bet
King Miller Over 94.5 rush yards (-114 at FanDuel)
Michigan ranks 32nd in success rate against the run and 45th in EPA/rush this season. Notre Dame ranks 41st and 35th, respectively, in those two metrics — and King Miller had successful outings against both of those defenses. He's going to have a field day against the Cornhuskers, who rank 108th in rushing success and 105th in EPA/rush and have already allowed 24 runs of 10+ yards in their five Big Ten games.
See our full analysis and Trojans/Cornhuskers SGP in our USC vs. Nebraska predictions.
Georgia Tech vs NC State best bet
Over 58.5 (-105 at FanDuel)
NC State has been one of the most efficient passing offenses in the country, ranking 18th in EPA per dropback. I think they lean into that for two reasons: First, I suspect they will be trailing; second, this Georgia Tech defense has not been great, particularly at limiting explosive plays. On the other side, Georgia Tech can largely take its pick of what to attack.
See our full analysis and Yellowjackets/Wolfpack SGP in our Georgia Tech vs. NC State predictions.
Kentucky vs Auburn best bet
Auburn -10.5 (-110 at FanDuel)
Kentucky’s offense does nothing well. The nicest thing that can be said about it is that it runs for a few yards at a time at a modest rate. Unfortunately for the Wildcats, Auburn’s defense ranks No. 3 in the country in rushing success rate against.
See our full analysis, and more of Douglas' best bets, in his college football predictions for Week 10.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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