The Detroit Pistons will look to extend their winning streak to 14 games as they visit the Boston Celtics tonight.
Detroit is the hottest team in the NBA, and I’m taking them to cover in my Pistons vs. Celtics predictions below.
Read on to see my full analysis of this NBA Cup matchup in my free NBA picks for Wednesday, November 26.
Pistons vs Celtics prediction
Pistons vs Celtics best bet: Pistons -2.5 (-110)
After starting the year 2-2, the Detroit Pistons have rattled off 13 straight wins and are showing no signs of slowing down. Detroit has been one of the NBA’s best defensive teams, allowing only 112.6 points per game and holding opponents to 44.5% shooting from the floor.
What’s made the Pistons so hard to beat, however, is their ability to combine stops with fairly efficient offense.
Cade Cunningham is off to an outstanding start, averaging 27.1 points and 9.6 assists per game. Jalen Duren (20.3 PPG) provides a constant presence in the paint, while the team has a depth of players who can explode when needed, such as Caris LeVert, who came off the bench to score 19 points against the Pacers on Monday.
The Boston Celtics are hanging in there without Jayson Tatum, but they don’t have anywhere near Detroit's depth. The lineup has become even shorter without center Neemias Queta, who suffered a left ankle sprain on Sunday against Indiana and has been ruled out for tonight.
That injury will make an already difficult matchup that much harder for Boston, allowing Duren to run wild in the paint. I’d already like the Pistons to defeat a healthy Celtics team, and I’m confidently taking Detroit to cover with the injury to Queta.
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Pistons vs Celtics same-game parlay
Along with taking the Pistons to win tonight, I’m also backing the Over, as Detroit has gone above the total in each of its last four games. I’ll also throw in a bet on Cunningham to hit the Over on his PRA total after coming in at 41+ PRA in each of his last 10 games.
Pistons vs Celtics SGP
- Pistons -2.5
- Over 231
- Cade Cunningham Over 41.5 points + rebounds + assists
Our "from downtown" SGP: Pistons keep on churning
Tobias Harris has hit at least one 3-pointer in every game this season, and has gone for two or more in three of his last five games.
Pistons vs Celtics SGP
- Pistons -2.5
- Over 231
- Cade Cunningham Over 41.5 points + rebounds + assists
- Tobias Harris Over 1.5 threes
Pistons vs Celtics odds
- Spread: Pistons -2.5 (-110) | Celtics +2.5 (-110)
- Moneyline: Pistons -150 | Celtics +125
- Over/Under: Over 231 (-110) | Under 231 (-110)
Pistons vs Celtics betting trend to know
The Pistons are 5-1 ATS in their last six games overall. Find more NBA betting trends for Pistons vs. Celtics.
How to watch Pistons vs Celtics
| Location | TD Garden, Boston, MA |
| Date | Wednesday, November 26, 2025 |
| Tip-off | 5:00 p.m. ET |
| TV | ESPN |
Pistons vs Celtics latest injuries
Not intended for use in MA.
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